null
SMILES: NC(=O)c1c(Nc2ccc(cc2Cl)N2CCNCC2)nc(Cc2c(Cl)cccc2Cl)c2nc[nH]c12
InChI Key: InChIKey=WXSOCJXALBBGME-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM196879 (US9212192, 42) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | <1 | <-12.3 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
AbbVie Inc. US Patent | Assay Description ALK kinase assays were conducted with the indicated final concentrations unless otherwise specified. In 384 well black plates (Axygen), 8 ul of compo... | US Patent US9212192 (2015) BindingDB Entry DOI: 10.7270/Q2D79971 | |||||||||||
More data for this Ligand-Target Pair |