BDBM196894 US9212192, 57
SMILES: CCc1nnc2c(C(N)=O)c(Nc3ccc(cc3OC)N3CCNCC3)nc(Cc3c(Cl)cccc3Cl)n12
InChI Key: InChIKey=QZYMNDLNGOMMHJ-UHFFFAOYSA-N
Data: 1 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM196894 (US9212192, 57) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 2 | -11.9 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
AbbVie Inc. US Patent | Assay Description ALK kinase assays were conducted with the indicated final concentrations unless otherwise specified. In 384 well black plates (Axygen), 8 ul of compo... | US Patent US9212192 (2015) BindingDB Entry DOI: 10.7270/Q2D79971 | |||||||||||
More data for this Ligand-Target Pair |