BDBM197114 US9216182, 1.60
SMILES: COC(=O)c1ccc(cn1)N1CCC(CC1)OC(=O)N1CCN(CC1)C1CCC1
InChI Key: InChIKey=BQNIRCRYSSTMJR-UHFFFAOYSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histamine H3 receptor (Homo sapiens (Human)) | BDBM197114 (US9216182, 1.60) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description The potency of compounds of the invention as H3 receptor antagonists can be assessed by measuring the blockade of (R)-alpha-methylhistamine-mediated ... | US Patent US9216182 (2015) BindingDB Entry DOI: 10.7270/Q2125RGW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H3 receptor (Homo sapiens (Human)) | BDBM197114 (US9216182, 1.60) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a | 7.5 | n/a |
Novartis AG US Patent | Assay Description The affinity of compounds of the invention to the H3 receptor can be assessed by measuring displacement of binding of the radioligand [3H]-N-α-Methy... | US Patent US9216182 (2015) BindingDB Entry DOI: 10.7270/Q2125RGW | |||||||||||
More data for this Ligand-Target Pair |