BDBM197173 Sinefungin
SMILES: Nc1ncnc2n(cnc12)[C@@H]1O[C@H](C[C@@H]([NH3+])CC[C@H]([NH3+])C([O-])=O)[C@@H](O)[C@H]1O
InChI Key: InChIKey=LMXOHSDXUQEUSF-YECHIGJVSA-O
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Nicotinamide N-methyltransferase (Homo sapiens (Human)) | BDBM197173 (Sinefungin) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a | 8.6 | 37 |
Utrecht University | Assay Description Enzyme activity assays were performed as previously described with NNMT (16.25 ug/mL, 550 nM) in 50 mM Tris buffer (pH 8.6) containing 1 mM DTT (all ... | Biochemistry 55: 5307-15 (2016) Article DOI: 10.1021/acs.biochem.6b00733 BindingDB Entry DOI: 10.7270/Q2H130TH | |||||||||||
More data for this Ligand-Target Pair |