BDBM198672 BDBM198673::BDBM198674::BDBM198675::BDBM198676::BDBM198719::BDBM198720::US9221796, 8

SMILES: OC1CN(CCC1c1ccc(O)cc1)C1CCN(Cc2ccc(F)cc2)C1=O

InChI Key: InChIKey=NIPVYFDEJFFCLH-UHFFFAOYSA-N

Data: 7 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 198672   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM198672 (BDBM198673 | BDBM198674 | BDBM198675 | BDBM198676 ...) Show SMILES OC1CN(CCC1c1ccc(O)cc1)C1CCN(Cc2ccc(F)cc2)C1=O Show InChI InChI=1S/C22H25FN2O3/c23-17-5-1-15(2-6-17)13-25-12-10-20(22(25)28)24-11-9-19(21(27)14-24)16-3-7-18(26)8-4-16/h1-8,19-21,26-27H,9-14H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5.70	-12.2	n/a	n/a	n/a	n/a	n/a	n/a	50
Bristol-Myers Squibb Company US Patent					Assay Description To perform the competition binding assay, thawed membrane homogenate was added to each well of a 96-well plate (20 ug/well). The experimental compo...				US Patent US9221796 (2015) BindingDB Entry DOI: 10.7270/Q20V8BK1
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM198672 (BDBM198673 | BDBM198674 | BDBM198675 | BDBM198676 ...) Show SMILES OC1CN(CCC1c1ccc(O)cc1)C1CCN(Cc2ccc(F)cc2)C1=O Show InChI InChI=1S/C22H25FN2O3/c23-17-5-1-15(2-6-17)13-25-12-10-20(22(25)28)24-11-9-19(21(27)14-24)16-3-7-18(26)8-4-16/h1-8,19-21,26-27H,9-14H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	160	-10.0	n/a	n/a	n/a	n/a	n/a	n/a	50
Bristol-Myers Squibb Company US Patent					Assay Description To perform the competition binding assay, thawed membrane homogenate was added to each well of a 96-well plate (20 ug/well). The experimental compo...				US Patent US9221796 (2015) BindingDB Entry DOI: 10.7270/Q20V8BK1
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM198672 (BDBM198673 | BDBM198674 | BDBM198675 | BDBM198676 ...) Show SMILES OC1CN(CCC1c1ccc(O)cc1)C1CCN(Cc2ccc(F)cc2)C1=O Show InChI InChI=1S/C22H25FN2O3/c23-17-5-1-15(2-6-17)13-25-12-10-20(22(25)28)24-11-9-19(21(27)14-24)16-3-7-18(26)8-4-16/h1-8,19-21,26-27H,9-14H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	180	-9.97	n/a	n/a	n/a	n/a	n/a	n/a	50
Bristol-Myers Squibb Company US Patent					Assay Description To perform the competition binding assay, thawed membrane homogenate was added to each well of a 96-well plate (20 ug/well). The experimental compo...				US Patent US9221796 (2015) BindingDB Entry DOI: 10.7270/Q20V8BK1
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM198672 (BDBM198673 | BDBM198674 | BDBM198675 | BDBM198676 ...) Show SMILES OC1CN(CCC1c1ccc(O)cc1)C1CCN(Cc2ccc(F)cc2)C1=O Show InChI InChI=1S/C22H25FN2O3/c23-17-5-1-15(2-6-17)13-25-12-10-20(22(25)28)24-11-9-19(21(27)14-24)16-3-7-18(26)8-4-16/h1-8,19-21,26-27H,9-14H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	420	-9.42	n/a	n/a	n/a	n/a	n/a	n/a	50
Bristol-Myers Squibb Company US Patent					Assay Description To perform the competition binding assay, thawed membrane homogenate was added to each well of a 96-well plate (20 ug/well). The experimental compo...				US Patent US9221796 (2015) BindingDB Entry DOI: 10.7270/Q20V8BK1
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM198672 (BDBM198673 | BDBM198674 | BDBM198675 | BDBM198676 ...) Show SMILES OC1CN(CCC1c1ccc(O)cc1)C1CCN(Cc2ccc(F)cc2)C1=O Show InChI InChI=1S/C22H25FN2O3/c23-17-5-1-15(2-6-17)13-25-12-10-20(22(25)28)24-11-9-19(21(27)14-24)16-3-7-18(26)8-4-16/h1-8,19-21,26-27H,9-14H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	650	-9.14	n/a	n/a	n/a	n/a	n/a	n/a	50
Bristol-Myers Squibb Company US Patent					Assay Description To perform the competition binding assay, thawed membrane homogenate was added to each well of a 96-well plate (20 ug/well). The experimental compo...				US Patent US9221796 (2015) BindingDB Entry DOI: 10.7270/Q20V8BK1
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM198672 (BDBM198673 | BDBM198674 | BDBM198675 | BDBM198676 ...) Show SMILES OC1CN(CCC1c1ccc(O)cc1)C1CCN(Cc2ccc(F)cc2)C1=O Show InChI InChI=1S/C22H25FN2O3/c23-17-5-1-15(2-6-17)13-25-12-10-20(22(25)28)24-11-9-19(21(27)14-24)16-3-7-18(26)8-4-16/h1-8,19-21,26-27H,9-14H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1.40E+3	-8.65	n/a	n/a	n/a	n/a	n/a	n/a	50
Bristol-Myers Squibb Company US Patent					Assay Description To perform the competition binding assay, thawed membrane homogenate was added to each well of a 96-well plate (20 ug/well). The experimental compo...				US Patent US9221796 (2015) BindingDB Entry DOI: 10.7270/Q20V8BK1
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM198672 (BDBM198673 | BDBM198674 | BDBM198675 | BDBM198676 ...) Show SMILES OC1CN(CCC1c1ccc(O)cc1)C1CCN(Cc2ccc(F)cc2)C1=O Show InChI InChI=1S/C22H25FN2O3/c23-17-5-1-15(2-6-17)13-25-12-10-20(22(25)28)24-11-9-19(21(27)14-24)16-3-7-18(26)8-4-16/h1-8,19-21,26-27H,9-14H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5.00E+3	-7.83	n/a	n/a	n/a	n/a	n/a	n/a	50
Bristol-Myers Squibb Company US Patent					Assay Description To perform the competition binding assay, thawed membrane homogenate was added to each well of a 96-well plate (20 ug/well). The experimental compo...				US Patent US9221796 (2015) BindingDB Entry DOI: 10.7270/Q20V8BK1
					More data for this Ligand-Target Pair