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BDBM198775 US9221796, 67

SMILES: Oc1ccc(cc1)[C@@H]1CCN(C[C@H]1F)[C@@H]1CCN(Cc2ccc(Cl)c(F)c2)C1=O

InChI Key: InChIKey=JATJVTHLUABLLD-RKGWXUTINA-N

Data: 1 KI

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 198775   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate receptor ionotropic, NMDA 2B


(Rattus norvegicus (Rat))
BDBM198775
PNG
(US9221796, 67)
Show SMILES Oc1ccc(cc1)[C@@H]1CCN(C[C@H]1F)[C@@H]1CCN(Cc2ccc(Cl)c(F)c2)C1=O |r|
Show InChI InChI=1/C22H23ClF2N2O2/c23-18-6-1-14(11-19(18)24)12-27-10-8-21(22(27)29)26-9-7-17(20(25)13-26)15-2-4-16(28)5-3-15/h1-6,11,17,20-21,28H,7-10,12-13H2/t17-,20+,21+/s2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
6.5 -12.1n/an/an/an/an/an/a50



Bristol-Myers Squibb Company

US Patent


Assay Description
To perform the competition binding assay, thawed membrane homogenate was added to each well of a 96-well plate (20 ug/well). The experimental compo...


US Patent US9221796 (2015)


BindingDB Entry DOI: 10.7270/Q20V8BK1
More data for this
Ligand-Target Pair