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SMILES: C=C(CN1CCOCC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1

InChI Key: InChIKey=KLOTUKMGLQKKIX-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 198881   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198881
PNG
(US9221797, 66)
Show SMILES C=C(CN1CCOCC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCCCC1 |t:28|
Show InChI InChI=1S/C24H27N5O2/c1-17(16-29-9-11-31-12-10-29)19-7-8-22(21(13-19)18-5-3-2-4-6-18)28-24(30)23-26-15-20(14-25)27-23/h5,7-8,13,15H,1-4,6,9-12,16H2,(H,26,27)(H,28,30)
UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 3.90n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair