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SMILES: CC(C)(OCCN1CCCC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1

InChI Key: InChIKey=SXHIZYRFWJFSEN-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 198894   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Macrophage colony-stimulating factor 1 receptor [555-568]


(Homo sapiens (Human))		BDBM198894
PNG
(US9221797, 80)
Show SMILES CC(C)(OCCN1CCCC1)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:30|
Show InChI InChI=1S/C28H37N5O2/c1-27(2)11-9-20(10-12-27)23-17-21(28(3,4)35-16-15-33-13-5-6-14-33)7-8-24(23)32-26(34)25-30-19-22(18-29)31-25/h7-9,17,19H,5-6,10-16H2,1-4H3,(H,30,31)(H,32,34)
UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 1.20n/an/an/an/a7.5n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CS...

US Patent US9221797 (2015)


BindingDB Entry DOI: 10.7270/Q2W37V4H
More data for this
Ligand-Target Pair