BDBM199127 N-(4-(1-(4,6-di(piperazin-1-yl)-1,3,5-triazin-2-yl)-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)phenyl)-4-methylbenzenesulphonamide (8i)
SMILES: COc1ccc(cc1)-c1cc(nn1-c1nc(nc(n1)N1CCNCC1)N1CCNCC1)-c1ccc(NS(=O)(=O)c2ccc(C)cc2)cc1
InChI Key: InChIKey=MZYOFVXOKOUHQS-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Matrix metalloproteinase-9 (MMP-9) (Rattus norvegicus (Rat)) | BDBM199127 (N-(4-(1-(4,6-di(piperazin-1-yl)-1,3,5-triazin-2-yl...) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 47.1 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Zhejiang Hospital | Assay Description where a pro-fluorescing peptide is used as substrate, and the fluorogenic activity of its cleavage product is measured after co-incubation with the a... | Chem Biol Drug Des 88: 756-765 (2016) Article DOI: 10.1111/cbdd.12807 BindingDB Entry DOI: 10.7270/Q2ZW1JR4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Matrix metalloproteinase-2 (MMP-2) (Rattus norvegicus (Rat)) | BDBM199127 (N-(4-(1-(4,6-di(piperazin-1-yl)-1,3,5-triazin-2-yl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 55.3 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Zhejiang Hospital | Assay Description where a pro-fluorescing peptide is used as substrate, and the fluorogenic activity of its cleavage product is measured after co-incubation with the a... | Chem Biol Drug Des 88: 756-765 (2016) Article DOI: 10.1111/cbdd.12807 BindingDB Entry DOI: 10.7270/Q2ZW1JR4 | |||||||||||
More data for this Ligand-Target Pair |