BDBM199211 US9216998, 16

SMILES: CN(C)CC(=O)N1CCn2c(CCc3ccccc3)c(c3cccc(C1)c23)C(F)(F)F

InChI Key: InChIKey=GFASAZHPYNPNGE-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 199211   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Endothelial lipase (EL) (Mus musculus (Mouse))	BDBM199211 (US9216998, 16) Show SMILES CN(C)CC(=O)N1CCn2c(CCc3ccccc3)c(c3cccc(C1)c23)C(F)(F)F Show InChI InChI=1S/C24H26F3N3O/c1-28(2)16-21(31)29-13-14-30-20(12-11-17-7-4-3-5-8-17)22(24(25,26)27)19-10-6-9-18(15-29)23(19)30/h3-10H,11-16H2,1-2H3	UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	7.2	n/a
Janssen Pharmaceutica NV US Patent					Assay Description To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...				US Patent US9216998 (2015) BindingDB Entry DOI: 10.7270/Q22N513F
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM199211 (US9216998, 16) Show SMILES CN(C)CC(=O)N1CCn2c(CCc3ccccc3)c(c3cccc(C1)c23)C(F)(F)F Show InChI InChI=1S/C24H26F3N3O/c1-28(2)16-21(31)29-13-14-30-20(12-11-17-7-4-3-5-8-17)22(24(25,26)27)19-10-6-9-18(15-29)23(19)30/h3-10H,11-16H2,1-2H3	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	959	n/a	n/a	n/a	n/a	7.2	n/a
Janssen Pharmaceutica NV US Patent					Assay Description To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...				US Patent US9216998 (2015) BindingDB Entry DOI: 10.7270/Q22N513F
					More data for this Ligand-Target Pair