BDBM199212 US9216998, 17

SMILES: NC(=N)N1CCn2c(CCc3ccccc3)c(c3cccc(C1)c23)C(F)(F)F

InChI Key: InChIKey=DHHAWTNLOXKDNN-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 199212   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Endothelial lipase (EL) (Mus musculus (Mouse))	BDBM199212 (US9216998, 17) Show SMILES NC(=N)N1CCn2c(CCc3ccccc3)c(c3cccc(C1)c23)C(F)(F)F Show InChI InChI=1S/C21H21F3N4/c22-21(23,24)18-16-8-4-7-15-13-27(20(25)26)11-12-28(19(15)16)17(18)10-9-14-5-2-1-3-6-14/h1-8H,9-13H2,(H3,25,26)	UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.62E+3	n/a	n/a	n/a	n/a	7.2	n/a
Janssen Pharmaceutica NV US Patent					Assay Description To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...				US Patent US9216998 (2015) BindingDB Entry DOI: 10.7270/Q22N513F
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM199212 (US9216998, 17) Show SMILES NC(=N)N1CCn2c(CCc3ccccc3)c(c3cccc(C1)c23)C(F)(F)F Show InChI InChI=1S/C21H21F3N4/c22-21(23,24)18-16-8-4-7-15-13-27(20(25)26)11-12-28(19(15)16)17(18)10-9-14-5-2-1-3-6-14/h1-8H,9-13H2,(H3,25,26)	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.82E+3	n/a	n/a	n/a	n/a	7.2	n/a
Janssen Pharmaceutica NV US Patent					Assay Description To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...				US Patent US9216998 (2015) BindingDB Entry DOI: 10.7270/Q22N513F
					More data for this Ligand-Target Pair