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BDBM19965 6-(4-methanesulfonylphenyl)-5-({4-[2-(piperidin-1-yl)ethoxy]phenyl}methyl)naphthalen-2-ol::LY2066948 analogue, 9

SMILES: CS(=O)(=O)c1ccc(cc1)-c1ccc2cc(O)ccc2c1Cc1ccc(OCCN2CCCCC2)cc1

InChI Key: InChIKey=FGQKZJQBKCJYLS-UHFFFAOYSA-N

Data: 2 KI  2 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 19965   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Estrogen receptor


(Homo sapiens (Human))
BDBM19965
PNG
(6-(4-methanesulfonylphenyl)-5-({4-[2-(piperidin-1-...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc2cc(O)ccc2c1Cc1ccc(OCCN2CCCCC2)cc1
Show InChI InChI=1S/C31H33NO4S/c1-37(34,35)28-13-7-24(8-14-28)29-15-9-25-22-26(33)10-16-30(25)31(29)21-23-5-11-27(12-6-23)36-20-19-32-17-3-2-4-18-32/h5-16,22,33H,2-4,17-21H2,1H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
1.15 -12.1n/an/a 4.78n/an/a7.522



Lilly Research Laboratories



Assay Description
The binding affinities were determined by a competitive radiometric binding assay using [3H]estradiol as tracer. The Kd for 3H-estradiol was determin...


J Med Chem 48: 6772-5 (2005)


Article DOI: 10.1021/jm050723z
BindingDB Entry DOI: 10.7270/Q2RR1WHW
More data for this
Ligand-Target Pair
Estradiol receptor beta (ERβ)


(Homo sapiens (Human))
BDBM19965
PNG
(6-(4-methanesulfonylphenyl)-5-({4-[2-(piperidin-1-...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc2cc(O)ccc2c1Cc1ccc(OCCN2CCCCC2)cc1
Show InChI InChI=1S/C31H33NO4S/c1-37(34,35)28-13-7-24(8-14-28)29-15-9-25-22-26(33)10-16-30(25)31(29)21-23-5-11-27(12-6-23)36-20-19-32-17-3-2-4-18-32/h5-16,22,33H,2-4,17-21H2,1H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
24.1 -10.3n/an/a 4.78n/an/a7.522



Lilly Research Laboratories



Assay Description
The binding affinities were determined by a competitive radiometric binding assay using [3H]estradiol as tracer. The Kd for 3H-estradiol was determin...


J Med Chem 48: 6772-5 (2005)


Article DOI: 10.1021/jm050723z
BindingDB Entry DOI: 10.7270/Q2RR1WHW
More data for this
Ligand-Target Pair