BDBM200329 US9227956, 14

SMILES: CCOC(=O)OC(C)OC(=O)c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1nccc2ccn(C)c12

InChI Key: InChIKey=RTJNOCVFOLRQLS-LEQGEALCSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 200329   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proprotein convertase subtilisin/kexin type 9 (PCSK9) (Homo sapiens (Human))	BDBM200329 (US9227956, 14) Show SMILES CCOC(=O)OC(C)OC(=O)c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1nccc2ccn(C)c12 |r| Show InChI InChI=1S/C30H34N6O6/c1-5-40-30(39)42-19(2)41-29(38)26-24(18-33-35(26)4)20-8-10-22(11-9-20)28(37)36(23-7-6-14-31-17-23)27-25-21(12-15-32-27)13-16-34(25)3/h8-13,15-16,18-19,23,31H,5-7,14,17H2,1-4H3/t19?,23-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...				US Patent US9227956 (2016) BindingDB Entry DOI: 10.7270/Q20R9N7M
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