BDBM200341 US9227956, 25

SMILES: Cn1ncc(c1C(=O)NO)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl

InChI Key: InChIKey=XLDXNXWIRIGEDI-MRXNPFEDSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 200341   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proprotein convertase subtilisin/kexin type 9 (PCSK9) (Homo sapiens (Human))	BDBM200341 (US9227956, 25) Show SMILES Cn1ncc(c1C(=O)NO)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl |r| Show InChI InChI=1S/C22H23ClN6O3/c1-28-19(21(30)27-32)17(13-26-28)14-6-8-15(9-7-14)22(31)29(16-4-2-10-24-12-16)20-18(23)5-3-11-25-20/h3,5-9,11,13,16,24,32H,2,4,10,12H2,1H3,(H,27,30)/t16-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.97E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...				US Patent US9227956 (2016) BindingDB Entry DOI: 10.7270/Q20R9N7M
					More data for this Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9) (Homo sapiens (Human))	BDBM200341 (US9227956, 25) Show SMILES Cn1ncc(c1C(=O)NO)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1Cl |r| Show InChI InChI=1S/C22H23ClN6O3/c1-28-19(21(30)27-32)17(13-26-28)14-6-8-15(9-7-14)22(31)29(16-4-2-10-24-12-16)20-18(23)5-3-11-25-20/h3,5-9,11,13,16,24,32H,2,4,10,12H2,1H3,(H,27,30)/t16-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...				US Patent US9227956 (2016) BindingDB Entry DOI: 10.7270/Q20R9N7M
					More data for this Ligand-Target Pair