BDBM200360 US9227956, 44::US9227956, 45

SMILES: CCC(=O)OC(C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C

InChI Key: InChIKey=UTFQKCKDAOKSGF-AVKWCDSFSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 200360   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proprotein convertase subtilisin/kexin type 9 (PCSK9) (Homo sapiens (Human))	BDBM200360 (US9227956, 44 | US9227956, 45) Show SMILES CCC(=O)OC(C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r| Show InChI InChI=1S/C28H33N9O3/c1-5-24(38)40-19(3)37-33-26(32-34-37)25-23(17-31-35(25)4)20-10-12-21(13-11-20)28(39)36(22-9-7-14-29-16-22)27-18(2)8-6-15-30-27/h6,8,10-13,15,17,19,22,29H,5,7,9,14,16H2,1-4H3/t19?,22-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...				US Patent US9227956 (2016) BindingDB Entry DOI: 10.7270/Q20R9N7M
					More data for this Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9) (Homo sapiens (Human))	BDBM200360 (US9227956, 44 | US9227956, 45) Show SMILES CCC(=O)OC(C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r| Show InChI InChI=1S/C28H33N9O3/c1-5-24(38)40-19(3)37-33-26(32-34-37)25-23(17-31-35(25)4)20-10-12-21(13-11-20)28(39)36(22-9-7-14-29-16-22)27-18(2)8-6-15-30-27/h6,8,10-13,15,17,19,22,29H,5,7,9,14,16H2,1-4H3/t19?,22-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.51E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...				US Patent US9227956 (2016) BindingDB Entry DOI: 10.7270/Q20R9N7M
					More data for this Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9) (Homo sapiens (Human))	BDBM200360 (US9227956, 44 | US9227956, 45) Show SMILES CCC(=O)OC(C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r| Show InChI InChI=1S/C28H33N9O3/c1-5-24(38)40-19(3)37-33-26(32-34-37)25-23(17-31-35(25)4)20-10-12-21(13-11-20)28(39)36(22-9-7-14-29-16-22)27-18(2)8-6-15-30-27/h6,8,10-13,15,17,19,22,29H,5,7,9,14,16H2,1-4H3/t19?,22-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.39E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...				US Patent US9227956 (2016) BindingDB Entry DOI: 10.7270/Q20R9N7M
					More data for this Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9) (Homo sapiens (Human))	BDBM200360 (US9227956, 44 | US9227956, 45) Show SMILES CCC(=O)OC(C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r| Show InChI InChI=1S/C28H33N9O3/c1-5-24(38)40-19(3)37-33-26(32-34-37)25-23(17-31-35(25)4)20-10-12-21(13-11-20)28(39)36(22-9-7-14-29-16-22)27-18(2)8-6-15-30-27/h6,8,10-13,15,17,19,22,29H,5,7,9,14,16H2,1-4H3/t19?,22-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...				US Patent US9227956 (2016) BindingDB Entry DOI: 10.7270/Q20R9N7M
					More data for this Ligand-Target Pair