BDBM200362 US9227956, 46::US9227956, 47

SMILES: CCC(OC(=O)CC)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C

InChI Key: InChIKey=ZHEWDNTVAUYWKL-LETIRJCYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 200362   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proprotein convertase subtilisin/kexin type 9 (PCSK9) (Homo sapiens (Human))	BDBM200362 (US9227956, 46 | US9227956, 47) Show SMILES CCC(OC(=O)CC)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r| Show InChI InChI=1S/C29H35N9O3/c1-5-24(41-25(39)6-2)38-34-27(33-35-38)26-23(18-32-36(26)4)20-11-13-21(14-12-20)29(40)37(22-10-8-15-30-17-22)28-19(3)9-7-16-31-28/h7,9,11-14,16,18,22,24,30H,5-6,8,10,15,17H2,1-4H3/t22-,24?/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...				US Patent US9227956 (2016) BindingDB Entry DOI: 10.7270/Q20R9N7M
					More data for this Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9) (Homo sapiens (Human))	BDBM200362 (US9227956, 46 | US9227956, 47) Show SMILES CCC(OC(=O)CC)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r| Show InChI InChI=1S/C29H35N9O3/c1-5-24(41-25(39)6-2)38-34-27(33-35-38)26-23(18-32-36(26)4)20-11-13-21(14-12-20)29(40)37(22-10-8-15-30-17-22)28-19(3)9-7-16-31-28/h7,9,11-14,16,18,22,24,30H,5-6,8,10,15,17H2,1-4H3/t22-,24?/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.34E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...				US Patent US9227956 (2016) BindingDB Entry DOI: 10.7270/Q20R9N7M
					More data for this Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9) (Homo sapiens (Human))	BDBM200362 (US9227956, 46 | US9227956, 47) Show SMILES CCC(OC(=O)CC)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r| Show InChI InChI=1S/C29H35N9O3/c1-5-24(41-25(39)6-2)38-34-27(33-35-38)26-23(18-32-36(26)4)20-11-13-21(14-12-20)29(40)37(22-10-8-15-30-17-22)28-19(3)9-7-16-31-28/h7,9,11-14,16,18,22,24,30H,5-6,8,10,15,17H2,1-4H3/t22-,24?/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.67E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...				US Patent US9227956 (2016) BindingDB Entry DOI: 10.7270/Q20R9N7M
					More data for this Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9) (Homo sapiens (Human))	BDBM200362 (US9227956, 46 | US9227956, 47) Show SMILES CCC(OC(=O)CC)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r| Show InChI InChI=1S/C29H35N9O3/c1-5-24(41-25(39)6-2)38-34-27(33-35-38)26-23(18-32-36(26)4)20-11-13-21(14-12-20)29(40)37(22-10-8-15-30-17-22)28-19(3)9-7-16-31-28/h7,9,11-14,16,18,22,24,30H,5-6,8,10,15,17H2,1-4H3/t22-,24?/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...				US Patent US9227956 (2016) BindingDB Entry DOI: 10.7270/Q20R9N7M
					More data for this Ligand-Target Pair