BDBM200364 US9227956, 48::US9227956, 49

SMILES: CCC(=O)OC(C(C)C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C

InChI Key: InChIKey=DQKQFOFKMRKEAX-ZCQJSQKNSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 200364   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proprotein convertase subtilisin/kexin type 9 (PCSK9) (Homo sapiens (Human))	BDBM200364 (US9227956, 48 | US9227956, 49) Show SMILES CCC(=O)OC(C(C)C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r| Show InChI InChI=1S/C30H37N9O3/c1-6-25(40)42-30(19(2)3)39-35-27(34-36-39)26-24(18-33-37(26)5)21-11-13-22(14-12-21)29(41)38(23-10-8-15-31-17-23)28-20(4)9-7-16-32-28/h7,9,11-14,16,18-19,23,30-31H,6,8,10,15,17H2,1-5H3/t23-,30?/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...				US Patent US9227956 (2016) BindingDB Entry DOI: 10.7270/Q20R9N7M
					More data for this Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9) (Homo sapiens (Human))	BDBM200364 (US9227956, 48 | US9227956, 49) Show SMILES CCC(=O)OC(C(C)C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r| Show InChI InChI=1S/C30H37N9O3/c1-6-25(40)42-30(19(2)3)39-35-27(34-36-39)26-24(18-33-37(26)5)21-11-13-22(14-12-21)29(41)38(23-10-8-15-31-17-23)28-20(4)9-7-16-32-28/h7,9,11-14,16,18-19,23,30-31H,6,8,10,15,17H2,1-5H3/t23-,30?/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.54E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...				US Patent US9227956 (2016) BindingDB Entry DOI: 10.7270/Q20R9N7M
					More data for this Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9) (Homo sapiens (Human))	BDBM200364 (US9227956, 48 | US9227956, 49) Show SMILES CCC(=O)OC(C(C)C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r| Show InChI InChI=1S/C30H37N9O3/c1-6-25(40)42-30(19(2)3)39-35-27(34-36-39)26-24(18-33-37(26)5)21-11-13-22(14-12-21)29(41)38(23-10-8-15-31-17-23)28-20(4)9-7-16-32-28/h7,9,11-14,16,18-19,23,30-31H,6,8,10,15,17H2,1-5H3/t23-,30?/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.68E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description In order to eliminate the permeability barrier inherent to the WT7 and SCHH cell-based assays a cell-free system was also established to access compo...				US Patent US9227956 (2016) BindingDB Entry DOI: 10.7270/Q20R9N7M
					More data for this Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9 (PCSK9) (Homo sapiens (Human))	BDBM200364 (US9227956, 48 | US9227956, 49) Show SMILES CCC(=O)OC(C(C)C)n1nnc(n1)-c1c(cnn1C)-c1ccc(cc1)C(=O)N([C@@H]1CCCNC1)c1ncccc1C |r| Show InChI InChI=1S/C30H37N9O3/c1-6-25(40)42-30(19(2)3)39-35-27(34-36-39)26-24(18-33-37(26)5)21-11-13-22(14-12-21)29(41)38(23-10-8-15-31-17-23)28-20(4)9-7-16-32-28/h7,9,11-14,16,18-19,23,30-31H,6,8,10,15,17H2,1-5H3/t23-,30?/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. US Patent					Assay Description An in-vitro AlphaLISA assay (Perkin Elmer) was developed in order to quantitate the level of PCSK9 secreted into the cell culture media following com...				US Patent US9227956 (2016) BindingDB Entry DOI: 10.7270/Q20R9N7M
					More data for this Ligand-Target Pair