Found 5 hits for monomerid = 200538 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
B-RAF V600E
(Homo sapiens (Human)) | BDBM200538
(US9670231, 1.47)Show SMILES CN(C)[C@H]1CCCN(C1)c1ccc(cc1C(F)(F)F)C(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12 |r| Show InChI InChI=1S/C32H32F3N5O4/c1-39(2)18-4-3-13-40(16-18)23-8-5-17(14-22(23)32(33,34)35)31(42)38-28-27-21-15-19(6-9-24(21)44-29(27)28)43-25-11-12-36-30-20(25)7-10-26(41)37-30/h5-6,8-9,11-12,14-15,18,27-29H,3-4,7,10,13,16H2,1-2H3,(H,38,42)(H,36,37,41)/t18-,27-,28-,29-/m0/s1 | PDB
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
BeiGene, Ltd.
US Patent
| Assay Description TBD |
US Patent US9670231 (2017)
BindingDB Entry DOI: 10.7270/Q2F18WWF |
More data for this Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM200538
(US9670231, 1.47)Show SMILES CN(C)[C@H]1CCCN(C1)c1ccc(cc1C(F)(F)F)C(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12 |r| Show InChI InChI=1S/C32H32F3N5O4/c1-39(2)18-4-3-13-40(16-18)23-8-5-17(14-22(23)32(33,34)35)31(42)38-28-27-21-15-19(6-9-24(21)44-29(27)28)43-25-11-12-36-30-20(25)7-10-26(41)37-30/h5-6,8-9,11-12,14-15,18,27-29H,3-4,7,10,13,16H2,1-2H3,(H,38,42)(H,36,37,41)/t18-,27-,28-,29-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
BeiGene, Ltd.
US Patent
| Assay Description TBD |
US Patent US9670231 (2017)
BindingDB Entry DOI: 10.7270/Q2F18WWF |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor(L858R, T790M)
(Homo sapiens (Human)) | BDBM200538
(US9670231, 1.47)Show SMILES CN(C)[C@H]1CCCN(C1)c1ccc(cc1C(F)(F)F)C(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12 |r| Show InChI InChI=1S/C32H32F3N5O4/c1-39(2)18-4-3-13-40(16-18)23-8-5-17(14-22(23)32(33,34)35)31(42)38-28-27-21-15-19(6-9-24(21)44-29(27)28)43-25-11-12-36-30-20(25)7-10-26(41)37-30/h5-6,8-9,11-12,14-15,18,27-29H,3-4,7,10,13,16H2,1-2H3,(H,38,42)(H,36,37,41)/t18-,27-,28-,29-/m0/s1 | PDB MMDB
KEGG
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 6.60 | n/a | n/a | n/a | n/a | n/a | n/a |
BeiGene, Ltd.
US Patent
| Assay Description TBD |
US Patent US9670231 (2017)
BindingDB Entry DOI: 10.7270/Q2F18WWF |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor(L858R)
(Homo sapiens (Human)) | BDBM200538
(US9670231, 1.47)Show SMILES CN(C)[C@H]1CCCN(C1)c1ccc(cc1C(F)(F)F)C(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12 |r| Show InChI InChI=1S/C32H32F3N5O4/c1-39(2)18-4-3-13-40(16-18)23-8-5-17(14-22(23)32(33,34)35)31(42)38-28-27-21-15-19(6-9-24(21)44-29(27)28)43-25-11-12-36-30-20(25)7-10-26(41)37-30/h5-6,8-9,11-12,14-15,18,27-29H,3-4,7,10,13,16H2,1-2H3,(H,38,42)(H,36,37,41)/t18-,27-,28-,29-/m0/s1 | PDB
GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.390 | n/a | n/a | n/a | n/a | n/a | n/a |
BeiGene, Ltd.
US Patent
| Assay Description TBD |
US Patent US9670231 (2017)
BindingDB Entry DOI: 10.7270/Q2F18WWF |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM200538
(US9670231, 1.47)Show SMILES CN(C)[C@H]1CCCN(C1)c1ccc(cc1C(F)(F)F)C(=O)N[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12 |r| Show InChI InChI=1S/C32H32F3N5O4/c1-39(2)18-4-3-13-40(16-18)23-8-5-17(14-22(23)32(33,34)35)31(42)38-28-27-21-15-19(6-9-24(21)44-29(27)28)43-25-11-12-36-30-20(25)7-10-26(41)37-30/h5-6,8-9,11-12,14-15,18,27-29H,3-4,7,10,13,16H2,1-2H3,(H,38,42)(H,36,37,41)/t18-,27-,28-,29-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
BeiGene, Ltd.
US Patent
| Assay Description TBD |
US Patent US9670231 (2017)
BindingDB Entry DOI: 10.7270/Q2F18WWF |
More data for this Ligand-Target Pair | |