BDBM20063 5-Substituted-6-chlorouracil, 7c::6-chloro-5-(prop-1-en-2-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione
SMILES: CC(=C)c1c(Cl)[nH]c(=O)[nH]c1=O
InChI Key: InChIKey=ALRXTIJXBSUQDY-UHFFFAOYSA-N
Data: 1 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Thymidine Phosphorylase (TP) (Homo sapiens (Human)) | BDBM20063 (5-Substituted-6-chlorouracil, 7c | 6-chloro-5-(pro...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 3.34E+3 | -7.77 | n/a | n/a | n/a | n/a | n/a | 6.4 | 37 |
Gilead Sciences Inc. | Assay Description The enzyme reaction was started by the addition of enzyme to the reaction mixture containing substrate and test compounds. The reaction was stopped b... | J Med Chem 50: 6016-23 (2007) Article DOI: 10.1021/jm070644i BindingDB Entry DOI: 10.7270/Q2M043PX | |||||||||||
More data for this Ligand-Target Pair |