BDBM200723 US9233086, 10L
SMILES: CCC(CC)(NC(=O)C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NC1(CCCC1)C(=O)NC(c1ccc(F)cc1)c1ccc(F)cc1
InChI Key: InChIKey=RZKSQRIPRKWVBU-MHZLTWQESA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
WD repeat-containing protein 5 (WDR5) (Homo sapiens (Human)) | BDBM200723 (US9233086, 10L) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | <1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Zhejiang Sci-Tech University Curated by ChEMBL | Assay Description Displacement of 5-FAM labelled tracer from WDR5 (unknown origin) by fluorescence polarization assay | Bioorg Med Chem Lett 29: 638-645 (2019) Article DOI: 10.1016/j.bmcl.2018.12.035 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Myeloid/lymphoid or mixed-lineage leukemia (MLL) (Homo sapiens (Human)) | BDBM200723 (US9233086, 10L) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | <1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of MLL1 binding to N-terminal His-tagged WRD5 23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli Roset... | Bioorg Med Chem 26: 356-365 (2018) Article DOI: 10.1016/j.bmc.2017.11.045 BindingDB Entry DOI: 10.7270/Q2SQ92ZS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MLL (Homo sapiens (Human)) | BDBM200723 (US9233086, 10L) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of recombinant MLL1 (unknown origin) interaction with recombinant ASH2L/RBBP5/WDR5 (unknown origin) assessed as decrease in histone methyl... | Bioorg Med Chem 24: 6109-6118 (2016) Article DOI: 10.1016/j.bmc.2016.09.073 BindingDB Entry DOI: 10.7270/Q2F47R4K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
WD repeat-containing protein 5 (WDR5) (Homo sapiens (Human)) | BDBM200723 (US9233086, 10L) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of C-terminal 5-FAM-WIN peptide binding to N-terminal His-tagged WDR5 (24 to 334 residues) (unknown origin) expressed in Rosetta2-(DE3) pL... | Bioorg Med Chem 24: 6109-6118 (2016) Article DOI: 10.1016/j.bmc.2016.09.073 BindingDB Entry DOI: 10.7270/Q2F47R4K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MLL (Homo sapiens (Human)) | BDBM200723 (US9233086, 10L) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of recombinant SUMO-fused MLL1/ASH2L/RBBP5/WDR5 complex histone methyltransferase activity (unknown origin) expressed in Escherichia coli ... | Eur J Med Chem 124: 480-489 (2016) Article DOI: 10.1016/j.ejmech.2016.08.036 BindingDB Entry DOI: 10.7270/Q2251M6G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
WD repeat-containing protein 5 (WDR5) (Homo sapiens (Human)) | BDBM200723 (US9233086, 10L) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Zhejiang Sci-Tech University Curated by ChEMBL | Assay Description Displacement of fluorescence-labelled Ac-ARA peptide from WDR5 (unknown origin) by fluorescence polarization assay | Bioorg Med Chem Lett 29: 638-645 (2019) Article DOI: 10.1016/j.bmcl.2018.12.035 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
WD repeat-containing protein 5 (WDR5) (Homo sapiens (Human)) | BDBM200723 (US9233086, 10L) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of fluorescence-labeled Ac-ARA peptide binding to WDR5 (unknown origin) by fluorescence polarization assay | Eur J Med Chem 124: 480-489 (2016) Article DOI: 10.1016/j.ejmech.2016.08.036 BindingDB Entry DOI: 10.7270/Q2251M6G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
WD repeat-containing protein 5 (WDR5) (Homo sapiens (Human)) | BDBM200723 (US9233086, 10L) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of 10mer-Thr-FAM probe binding to human WDR5 after 2 hrs by fluorescence polarization assay | Eur J Med Chem 124: 480-489 (2016) Article DOI: 10.1016/j.ejmech.2016.08.036 BindingDB Entry DOI: 10.7270/Q2251M6G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Myeloid/lymphoid or mixed-lineage leukemia (MLL) (Homo sapiens (Human)) | BDBM200723 (US9233086, 10L) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of MLL1 binding to N-terminal His-tagged WRD5 23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli Roset... | Bioorg Med Chem 26: 356-365 (2018) Article DOI: 10.1016/j.bmc.2017.11.045 BindingDB Entry DOI: 10.7270/Q2SQ92ZS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MLL (Homo sapiens (Human)) | BDBM200723 (US9233086, 10L) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of His-SUMO-fused MLL1 (3762 to 3969 residues) interaction with His-SUMO-fused ASH2L/RBBP5/WDR5 (23 to 334 residues) (unknown origin) expr... | Bioorg Med Chem 24: 6109-6118 (2016) Article DOI: 10.1016/j.bmc.2016.09.073 BindingDB Entry DOI: 10.7270/Q2F47R4K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
WD repeat-containing protein 5 (WDR5) (Homo sapiens (Human)) | BDBM200723 (US9233086, 10L) | PDB MMDB B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | <3.00E+3 | n/a | n/a | n/a | n/a | 6.5 | 25 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent | Assay Description N-terminal His-tagged WDR5Δ23 (residues 24-334) was expressed from the pET28-MHL vector in Rosetta2(DE3) pLysS cells (Novagen). Cells were grown... | US Patent US9233086 (2016) BindingDB Entry DOI: 10.7270/Q27943GX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MLL (Homo sapiens (Human)) | BDBM200723 (US9233086, 10L) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 750 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of recombinant MLL1/ASH2L/RBBP5/WDR5 complex histone methyltransferase activity (unknown origin) by AlphaScreen assay | Eur J Med Chem 124: 480-489 (2016) Article DOI: 10.1016/j.ejmech.2016.08.036 BindingDB Entry DOI: 10.7270/Q2251M6G | |||||||||||
More data for this Ligand-Target Pair |