BDBM200832 2-[2-((2s,3's)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)-pyrimidin-5-yl]-1-oxo-2,8-diaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester::US9533995, 12

SMILES: C[C@H]1CCCN1[C@H]1CCN(C1)c1ncc(cn1)N1CCC2(CCN(CC2)C(=O)OC(C)(C)C)C1=O

InChI Key: InChIKey=VHORAPZFCRPSQS-PMACEKPBSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 200832   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine receptor H3 (Macaca mulatta (Rhesus macaque))	BDBM200832 (2-[2-((2s,3's)-2-methyl-[1,3']bipyrrolidin...) Show SMILES C[C@H]1CCCN1[C@H]1CCN(C1)c1ncc(cn1)N1CCC2(CCN(CC2)C(=O)OC(C)(C)C)C1=O |r| Show InChI InChI=1S/C26H40N6O3/c1-19-6-5-11-31(19)20-7-12-30(18-20)23-27-16-21(17-28-23)32-15-10-26(22(32)33)8-13-29(14-9-26)24(34)35-25(2,3)4/h16-17,19-20H,5-15,18H2,1-4H3/t19-,20-/m0/s1	UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	48.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Sanofi US Patent					Assay Description Rhesus H3 radioligand binding assay was performed using rhesus H3 receptor membranes (prepared as described above), [3H]-Methylhistamine (Perkin Elme...				US Patent US9533995 (2017) BindingDB Entry DOI: 10.7270/Q25H7DFS
					More data for this Ligand-Target Pair