BDBM200862 US9533999, i-18

SMILES: COC(=O)c1ccc2c(n1)N(Cc1ccc(F)c(OC(F)(F)F)c1)C(=O)CS2(=O)=O

InChI Key: InChIKey=JQSANEJRICRWIB-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 200862   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Intermediate conductance calcium-activated potassium channel protein 4 (Homo sapiens (Human))	BDBM200862 (US9533999, i-18) Show SMILES COC(=O)c1ccc2c(n1)N(Cc1ccc(F)c(OC(F)(F)F)c1)C(=O)CS2(=O)=O Show InChI InChI=1S/C17H12F4N2O6S/c1-28-16(25)11-4-5-13-15(22-11)23(14(24)8-30(13,26)27)7-9-2-3-10(18)12(6-9)29-17(19,20)21/h2-6H,7-8H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	88	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...				US Patent US9533999 (2017) BindingDB Entry DOI: 10.7270/Q21V5C4S
					More data for this Ligand-Target Pair