BDBM200971 US9533999, ii-22

SMILES: Cc1nc2N(Cc3cccc(c3)C(F)(F)F)C(=O)CSc2s1

InChI Key: InChIKey=HFJORJWNMYDZHQ-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 200971   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Intermediate conductance calcium-activated potassium channel protein 4 (Homo sapiens (Human))	BDBM200971 (US9533999, ii-22) Show SMILES Cc1nc2N(Cc3cccc(c3)C(F)(F)F)C(=O)CSc2s1 Show InChI InChI=1S/C14H11F3N2OS2/c1-8-18-12-13(22-8)21-7-11(20)19(12)6-9-3-2-4-10(5-9)14(15,16)17/h2-5H,6-7H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description HEK293 cells over-expressing human KCa3.1 are used to measure the effects of compounds in inhibiting the KCa3.1 channel function. The assay is based ...				US Patent US9533999 (2017) BindingDB Entry DOI: 10.7270/Q21V5C4S
					More data for this Ligand-Target Pair