BDBM20157 1-benzyl-3-phenyl-4-(phenylamino)-2,5-dihydro-1H-pyrrole-2,5-dione::GSK3987 Analogue::Substituted Maleimide, 5

SMILES: O=C1N(Cc2ccccc2)C(=O)C(=C1Nc1ccccc1)c1ccccc1

InChI Key: InChIKey=GLDDBILAEOMQJI-UHFFFAOYSA-N

Data: 2 EC50

PDB links: 1 PDB ID contains this monomer as substructures. 1 PDB ID contains inhibitors having a similarity of 90% to this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 20157   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM20157 (1-benzyl-3-phenyl-4-(phenylamino)-2,5-dihydro-1H-p...) Show SMILES O=C1N(Cc2ccccc2)C(=O)C(=C1Nc1ccccc1)c1ccccc1 |c:13| Show InChI InChI=1S/C23H18N2O2/c26-22-20(18-12-6-2-7-13-18)21(24-19-14-8-3-9-15-19)23(27)25(22)16-17-10-4-1-5-11-17/h1-15,24H,16H2	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	70	n/a	n/a	7.5	22
GlaxoSmithKline					Assay Description The LXR LiSA measures the ligand-dependent recruitment of a 25 amino acid fragment of the steroid receptor coactivator 1 (SRC1) to the ligand-binding...				J Med Chem 48: 5419-22 (2005) Article DOI: 10.1021/jm050532w BindingDB Entry DOI: 10.7270/Q26T0JXG
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-alpha (Homo sapiens (Human))	BDBM20157 (1-benzyl-3-phenyl-4-(phenylamino)-2,5-dihydro-1H-p...) Show SMILES O=C1N(Cc2ccccc2)C(=O)C(=C1Nc1ccccc1)c1ccccc1 |c:13| Show InChI InChI=1S/C23H18N2O2/c26-22-20(18-12-6-2-7-13-18)21(24-19-14-8-3-9-15-19)23(27)25(22)16-17-10-4-1-5-11-17/h1-15,24H,16H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	100	n/a	n/a	7.5	22
GlaxoSmithKline					Assay Description The LXR LiSA measures the ligand-dependent recruitment of a 25 amino acid fragment of the steroid receptor coactivator 1 (SRC1) to the ligand-binding...				J Med Chem 48: 5419-22 (2005) Article DOI: 10.1021/jm050532w BindingDB Entry DOI: 10.7270/Q26T0JXG
					More data for this Ligand-Target Pair