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SMILES: OCc1c(cc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C1COC1)N1CCOc2cc(ccc2C1=O)C1CC1

InChI Key: InChIKey=SUQBBJGPOVPMSO-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 202202   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))		BDBM202202
PNG
(US9233983, P-17)
Show SMILES OCc1c(cc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)C1COC1)N1CCOc2cc(ccc2C1=O)C1CC1 |t:21|
Show InChI InChI=1S/C34H33FN4O4/c35-23-14-27(25-5-8-36-33-28(25)16-30(37-33)21-6-9-38(10-7-21)24-18-42-19-24)29(17-40)31(15-23)39-11-12-43-32-13-22(20-1-2-20)3-4-26(32)34(39)41/h3-6,8,13-16,20,24,40H,1-2,7,9-12,17-19H2,(H,36,37)
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KEGG

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PC cid
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US Patent
n/an/a 2.5n/an/an/an/an/an/a



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
The inhibition assays were performed using the generic tyrosine kinase assay kit from C is Bio (HTRF KinEASE-TK #62TK0PEB). The assay is based on t...

US Patent US9233983 (2016)


BindingDB Entry DOI: 10.7270/Q22J69PQ
More data for this
Ligand-Target Pair