BDBM202553 (E/Z)-2-cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)furan-2-yl)-N,N-dimethylacrylamide (4)
SMILES: CN(C)C(=O)C(=C\c1ccc(o1)-c1nc2cnc3[nH]ccc3c2n1C1CCCCC1)\C#N
InChI Key: InChIKey=GJMZWYLOARVASY-NTCAYCPXSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
JAK3 (aa 781-1124) (Homo sapiens (Human)) | BDBM202553 ((E/Z)-2-cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidaz...) | PDB GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University Tuebingen | Assay Description In this ELISA-based kinase activity assay, a 96-well assay plate is coated with an artificial polypeptide serving as kinase substrate that contains t... | Cell Chem Biol 23: 1335-1340 (2016) Article DOI: 10.1016/j.chembiol.2016.10.008 BindingDB Entry DOI: 10.7270/Q2WS8S22 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 (Homo sapiens (Human)) | BDBM202553 ((E/Z)-2-cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidaz...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University Tuebingen | Assay Description A commercial assay by Reaction Biology Corp. | Cell Chem Biol 23: 1335-1340 (2016) Article DOI: 10.1016/j.chembiol.2016.10.008 BindingDB Entry DOI: 10.7270/Q2WS8S22 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK2 (Homo sapiens (Human)) | BDBM202553 ((E/Z)-2-cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidaz...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 346 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University Tuebingen | Assay Description A commercial assay by Reaction Biology Corp. | Cell Chem Biol 23: 1335-1340 (2016) Article DOI: 10.1016/j.chembiol.2016.10.008 BindingDB Entry DOI: 10.7270/Q2WS8S22 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK3 (Homo sapiens (Human)) | BDBM202553 ((E/Z)-2-cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidaz...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.127 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University Tuebingen | Assay Description A commercial assay by Reaction Biology Corp. | Cell Chem Biol 23: 1335-1340 (2016) Article DOI: 10.1016/j.chembiol.2016.10.008 BindingDB Entry DOI: 10.7270/Q2WS8S22 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human)) | BDBM202553 ((E/Z)-2-cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidaz...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University Tuebingen | Assay Description The assay is based on the displacement of a reporter probe by a test compound. Close proximity of the probe and the targeted kinase result in emissio... | Cell Chem Biol 23: 1335-1340 (2016) Article DOI: 10.1016/j.chembiol.2016.10.008 BindingDB Entry DOI: 10.7270/Q2WS8S22 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 (Homo sapiens (Human)) | BDBM202553 ((E/Z)-2-cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidaz...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 69.7 | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University Tuebingen | Assay Description The assay is based on the displacement of a reporter probe by a test compound. Close proximity of the probe and the targeted kinase result in emissio... | Cell Chem Biol 23: 1335-1340 (2016) Article DOI: 10.1016/j.chembiol.2016.10.008 BindingDB Entry DOI: 10.7270/Q2WS8S22 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK2 (Homo sapiens (Human)) | BDBM202553 ((E/Z)-2-cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidaz...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 242 | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University Tuebingen | Assay Description The assay is based on the displacement of a reporter probe by a test compound. Close proximity of the probe and the targeted kinase result in emissio... | Cell Chem Biol 23: 1335-1340 (2016) Article DOI: 10.1016/j.chembiol.2016.10.008 BindingDB Entry DOI: 10.7270/Q2WS8S22 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK3 (Homo sapiens (Human)) | BDBM202553 ((E/Z)-2-cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidaz...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 1.34 | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University Tuebingen | Assay Description The assay is based on the displacement of a reporter probe by a test compound. Close proximity of the probe and the targeted kinase result in emissio... | Cell Chem Biol 23: 1335-1340 (2016) Article DOI: 10.1016/j.chembiol.2016.10.008 BindingDB Entry DOI: 10.7270/Q2WS8S22 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human)) | BDBM202553 ((E/Z)-2-cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidaz...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 459 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University Tuebingen | Assay Description A commercial assay by Reaction Biology Corp. | Cell Chem Biol 23: 1335-1340 (2016) Article DOI: 10.1016/j.chembiol.2016.10.008 BindingDB Entry DOI: 10.7270/Q2WS8S22 | |||||||||||
More data for this Ligand-Target Pair |