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null

SMILES: C[C@@H]1CCCC[C@@H]1n1c(nc2cnc3[nH]ccc3c12)-c1ccc(\C=C(/C#N)C(=O)N(C)C)o1

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 202554
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Tyrosine-protein kinase JAK3 [781-1124] (Homo sapiens (Human))	BDBM202554 ((E/Z)-2-cyano-N,N-dimethyl-3-(5-(1-((1S,2R)-2-meth...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard-Karls-University Tuebingen					Assay Description In this ELISA-based kinase activity assay, a 96-well assay plate is coated with an artificial polypeptide serving as kinase substrate that contains t...				Cell Chem Biol 23: 1335-1340 (2016) Article DOI: 10.1016/j.chembiol.2016.10.008 BindingDB Entry DOI: 10.7270/Q2WS8S22
Eberhard-Karls-University Tuebingen					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM202554 ((E/Z)-2-cyano-N,N-dimethyl-3-(5-(1-((1S,2R)-2-meth...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	64	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard-Karls-University Tuebingen					Assay Description A commercial assay by Reaction Biology Corp.				Cell Chem Biol 23: 1335-1340 (2016) Article DOI: 10.1016/j.chembiol.2016.10.008 BindingDB Entry DOI: 10.7270/Q2WS8S22
Eberhard-Karls-University Tuebingen					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM202554 ((E/Z)-2-cyano-N,N-dimethyl-3-(5-(1-((1S,2R)-2-meth...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	898	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard-Karls-University Tuebingen					Assay Description A commercial assay by Reaction Biology Corp.				Cell Chem Biol 23: 1335-1340 (2016) Article DOI: 10.1016/j.chembiol.2016.10.008 BindingDB Entry DOI: 10.7270/Q2WS8S22
Eberhard-Karls-University Tuebingen					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM202554 ((E/Z)-2-cyano-N,N-dimethyl-3-(5-(1-((1S,2R)-2-meth...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.154	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard-Karls-University Tuebingen					Assay Description A commercial assay by Reaction Biology Corp.				Cell Chem Biol 23: 1335-1340 (2016) Article DOI: 10.1016/j.chembiol.2016.10.008 BindingDB Entry DOI: 10.7270/Q2WS8S22
Eberhard-Karls-University Tuebingen					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM202554 ((E/Z)-2-cyano-N,N-dimethyl-3-(5-(1-((1S,2R)-2-meth...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
Eberhard-Karls-University Tuebingen					Assay Description A commercial assay by Reaction Biology Corp.				Cell Chem Biol 23: 1335-1340 (2016) Article DOI: 10.1016/j.chembiol.2016.10.008 BindingDB Entry DOI: 10.7270/Q2WS8S22
Eberhard-Karls-University Tuebingen					More data for this Ligand-Target Pair