BDBM204093 US9539260, F10::US9763952, Example F10

SMILES: COc1ncc(cc1C(F)F)N1CCOc2cnc(O[C@H]3CCN(C3)C(=O)c3cn(C)cn3)cc12

InChI Key: InChIKey=KXXNDPMDRAXPQN-HNNXBMFYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 204093   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM204093 (US9539260, F10 | US9763952, Example F10) Show SMILES COc1ncc(cc1C(F)F)N1CCOc2cnc(O[C@H]3CCN(C3)C(=O)c3cn(C)cn3)cc12 |r| Show InChI InChI=1S/C23H24F2N6O4/c1-29-12-17(28-13-29)23(32)30-4-3-15(11-30)35-20-8-18-19(10-26-20)34-6-5-31(18)14-7-16(21(24)25)22(33-2)27-9-14/h7-10,12-13,15,21H,3-6,11H2,1-2H3/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	25
NOVARTIS AG US Patent					Assay Description Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...				US Patent US9539260 (2017) BindingDB Entry DOI: 10.7270/Q2W37TH1
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM204093 (US9539260, F10 | US9763952, Example F10) Show SMILES COc1ncc(cc1C(F)F)N1CCOc2cnc(O[C@H]3CCN(C3)C(=O)c3cn(C)cn3)cc12 |r| Show InChI InChI=1S/C23H24F2N6O4/c1-29-12-17(28-13-29)23(32)30-4-3-15(11-30)35-20-8-18-19(10-26-20)34-6-5-31(18)14-7-16(21(24)25)22(33-2)27-9-14/h7-10,12-13,15,21H,3-6,11H2,1-2H3/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<3	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent									US Patent US9763952 (2017) BindingDB Entry DOI: 10.7270/Q2V40X9Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM204093 (US9539260, F10 | US9763952, Example F10) Show SMILES COc1ncc(cc1C(F)F)N1CCOc2cnc(O[C@H]3CCN(C3)C(=O)c3cn(C)cn3)cc12 |r| Show InChI InChI=1S/C23H24F2N6O4/c1-29-12-17(28-13-29)23(32)30-4-3-15(11-30)35-20-8-18-19(10-26-20)34-6-5-31(18)14-7-16(21(24)25)22(33-2)27-9-14/h7-10,12-13,15,21H,3-6,11H2,1-2H3/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
NOVARTIS AG US Patent					Assay Description The kinase reaction is performed in a final volume of 50 μl per well of a half area COSTAR, 96 well plate. The final concentrations of ATP and p...				US Patent US9763952 (2017) BindingDB Entry DOI: 10.7270/Q2V40X9Z
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM204093 (US9539260, F10 | US9763952, Example F10) Show SMILES COc1ncc(cc1C(F)F)N1CCOc2cnc(O[C@H]3CCN(C3)C(=O)c3cn(C)cn3)cc12 |r| Show InChI InChI=1S/C23H24F2N6O4/c1-29-12-17(28-13-29)23(32)30-4-3-15(11-30)35-20-8-18-19(10-26-20)34-6-5-31(18)14-7-16(21(24)25)22(33-2)27-9-14/h7-10,12-13,15,21H,3-6,11H2,1-2H3/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<3	n/a	n/a	n/a	n/a	n/a	25
NOVARTIS AG US Patent					Assay Description Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...				US Patent US9539260 (2017) BindingDB Entry DOI: 10.7270/Q2W37TH1
					More data for this Ligand-Target Pair