BDBM20460 (9Z)-N-[(4-hydroxy-3-methoxyphenyl)methyl]octadec-9-enamide::(Z)-N-[(4-hydroxy-3-methoxyphenyl)methyl]octadec-9-enamide::CHEMBL76903::N-Vannilyloleoylamide::Olvanil
SMILES: CCCCCCCC\C=C/CCCCCCCC(=O)NCc1ccc(O)c(OC)c1
InChI Key: InChIKey=OPZKBPQVWDSATI-KHPPLWFESA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human)) | BDBM20460 ((9Z)-N-[(4-hydroxy-3-methoxyphenyl)methyl]octadec-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.59E+3 | -7.91 | n/a | n/a | 132 | n/a | n/a | 7.4 | 25 |
Abbott Laboratories | Assay Description The hTRPV1-expressing CHO cell membranes were incubated with [3H]A-778317 and test compounds to establish equilibrium. After incubation was terminate... | J Pharmacol Exp Ther 323: 285-93 (2007) Article DOI: 10.1124/jpet.107.124305 BindingDB Entry DOI: 10.7270/Q28K77B0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vanilloid receptor (Rattus norvegicus-Rattus norvegicus (rat)) | BDBM20460 ((9Z)-N-[(4-hydroxy-3-methoxyphenyl)methyl]octadec-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 170 | n/a | n/a | n/a | n/a |
Sandoz Institute for Medical Research Curated by ChEMBL | Assay Description Compound tested in vitro for [Ca2+] influx into neonatal rat dorsal root ganglia (DRG) | J Med Chem 39: 4942-51 (1996) Article DOI: 10.1021/jm960512h BindingDB Entry DOI: 10.7270/Q2XP77PD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vanilloid receptor (Rattus norvegicus) | BDBM20460 ((9Z)-N-[(4-hydroxy-3-methoxyphenyl)methyl]octadec-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
National Research Council (CNR) Curated by ChEMBL | Assay Description Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins foll... | J Med Chem 61: 8255-8281 (2018) Article DOI: 10.1021/acs.jmedchem.8b00734 BindingDB Entry DOI: 10.7270/Q2222XFP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vanilloid receptor (Homo sapiens (Human)) | BDBM20460 ((9Z)-N-[(4-hydroxy-3-methoxyphenyl)methyl]octadec-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.501 | n/a | n/a | n/a | n/a |
Istituto per la Chimica di Molecole di Interesse Biologico Curated by ChEMBL | Assay Description Concentration necessary to induce a relative half-maximal response measured by the entry of [Ca2+] into human embryonic kidney HEK293 cells overexpre... | J Med Chem 45: 3739-45 (2002) Article DOI: 10.1021/jm020844o BindingDB Entry DOI: 10.7270/Q23F4SDF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vanilloid receptor (Rattus norvegicus-Rattus norvegicus (rat)) | BDBM20460 ((9Z)-N-[(4-hydroxy-3-methoxyphenyl)methyl]octadec-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 170 | n/a | n/a | n/a | n/a |
Sandoz Institute for Medical Research Curated by ChEMBL | Assay Description In vitro effective concentration for Ca++ uptake into dorsal root ganglia neurones in culture | J Med Chem 36: 2381-9 (1993) Article DOI: 10.1021/jm00068a016 BindingDB Entry DOI: 10.7270/Q2SB4801 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vanilloid receptor (Rattus norvegicus) | BDBM20460 ((9Z)-N-[(4-hydroxy-3-methoxyphenyl)methyl]octadec-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Research Council (CNR) Curated by ChEMBL | Assay Description Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of CBD-induced Ca2+ levels preincubated for 5 mins foll... | J Med Chem 61: 8255-8281 (2018) Article DOI: 10.1021/acs.jmedchem.8b00734 BindingDB Entry DOI: 10.7270/Q2222XFP | |||||||||||
More data for this Ligand-Target Pair |