BDBM20488 (2E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-enamide::SB-366791
SMILES: COc1cccc(NC(=O)\C=C\c2ccc(Cl)cc2)c1
InChI Key: InChIKey=RYAMDQKWNKKFHD-JXMROGBWSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human)) | BDBM20488 ((2E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 20 | n/a | n/a | 7.2 | 25 |
GSK | Assay Description One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h... | Bioorg Med Chem Lett 14: 3631-4 (2004) Article DOI: 10.1016/j.bmcl.2004.05.028 BindingDB Entry DOI: 10.7270/Q24T6GM8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human)) | BDBM20488 ((2E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
Sapienza Universit£ di Roma Curated by ChEMBL | Assay Description Antagonist activity at recombinant human TRPV1 channel expressed in CHO cells assessed as inhibition of capsiacin-induced Ca2+ flux by Fluo-3 dye bas... | Bioorg Med Chem Lett 26: 1401-5 (2016) BindingDB Entry DOI: 10.7270/Q24F1SM9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fatty-acid amide hydrolase 1 (aa 30-579) (Rattus norvegicus (rat)) | BDBM20488 ((2E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-...) | PDB MMDB B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sapienza Universit£ di Roma Curated by ChEMBL | Assay Description Inhibition of rat brain FAAH assessed as hydrolysis of [14C]AEA to [14C]Ethanolamine incubated for 30 mins by scintillation counting method | Bioorg Med Chem Lett 26: 1401-5 (2016) BindingDB Entry DOI: 10.7270/Q24F1SM9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human)) | BDBM20488 ((2E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Sapienza Universit£ di Roma Curated by ChEMBL | Assay Description Antagonist activity at recombinant human TRPV1 channel expressed in CHO cells assessed as inhibition of capsiacin-induced Ca2+ flux by Fluo-3 dye bas... | Bioorg Med Chem Lett 26: 1401-5 (2016) BindingDB Entry DOI: 10.7270/Q24F1SM9 | |||||||||||
More data for this Ligand-Target Pair |