BDBM205422 US9243020, 9::US9815861, Example 9
SMILES: CNC1=N[C@H]2[C@H](O[C@H](CO)[C@@H](O)[C@@H]2F)S1
InChI Key: InChIKey=KFTTUHTWIAVGRH-NYMZXIIRSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase) (Homo sapiens (Human)) | BDBM205422 (US9243020, 9 | US9815861, Example 9) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Alectos Therapeutics, Inc.; Merck Sharp & Dohme Corp. US Patent | Assay Description Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet... | US Patent US9815861 (2017) BindingDB Entry DOI: 10.7270/Q2R78HJ8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase) (Homo sapiens (Human)) | BDBM205422 (US9243020, 9 | US9815861, Example 9) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 1.30 | -12.1 | n/a | n/a | n/a | n/a | n/a | 7.0 | 25 |
Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp. US Patent | Assay Description Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet... | US Patent US9243020 (2016) BindingDB Entry DOI: 10.7270/Q2542MD4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase) (Homo sapiens (Human)) | BDBM205422 (US9243020, 9 | US9815861, Example 9) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co. Curated by ChEMBL | Assay Description Inhibition of recombinant human OGA | J Med Chem 62: 10062-10097 (2019) Article DOI: 10.1021/acs.jmedchem.9b01090 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-hexosaminidase subunit beta (Hex B) (Homo sapiens (Human)) | BDBM205422 (US9243020, 9 | US9815861, Example 9) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 8.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co. Curated by ChEMBL | Assay Description Inhibition of human beta hexosaminidase assessed as inhibitory constant using 4-methylumbelliferyl N-acetyl-beta-D-glucosaminide dihydrate as substra... | J Med Chem 62: 10062-10097 (2019) Article DOI: 10.1021/acs.jmedchem.9b01090 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein O-GlcNAcase (Rattus norvegicus) | BDBM205422 (US9243020, 9 | US9815861, Example 9) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 307 | n/a | n/a | n/a | n/a |
Merck & Co. Curated by ChEMBL | Assay Description Inhibition of OGA in rat PC12 cells assessed as OGlcNAcylated protein level incubated for 24 hrs by ELISA | J Med Chem 62: 10062-10097 (2019) Article DOI: 10.1021/acs.jmedchem.9b01090 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
N-acetyl-beta-D-glucosaminidase (O-GlcNAcase) (Homo sapiens (Human)) | BDBM205422 (US9243020, 9 | US9815861, Example 9) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 307 | n/a | n/a | n/a | 4 |
Alectos Therapeutics Inc.; Merck Sharp & Dohme Corp. US Patent | Assay Description The ELISA portion of the assay was performed in a black Maxisorp 96-well plate that was coated overnight at 4° C. with 100 uL/well of the cell ly... | US Patent US9243020 (2016) BindingDB Entry DOI: 10.7270/Q2542MD4 | |||||||||||
More data for this Ligand-Target Pair |