BDBM205435 (6S+2S)-PEG7 (11)
SMILES: COC(=O)C[C@@H]1N=C(c2c(C)c(sc2-n2c(C)nnc12)C(=O)NCCOCCOCCOCCOCCOCCOCCOCCNC(=O)C[C@@H]1N=C(c2c(C)c(C)sc2-n2c(C)nnc12)c1ccc(Cl)cc1)c1ccc(Cl)cc1
InChI Key: InChIKey=WHJGVHRMVTVKHR-MJPWBCPGSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Bromodomain-containing protein 4 (BRD4) (aa 44-168) (Homo sapiens (Human)) | BDBM205435 ((6S+2S)-PEG7 (11)) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 0.0260 | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute | Assay Description Refer to DiscoverX | Nat Chem Biol 12: 1089-1096 (2016) Article DOI: 10.1038/nchembio.2209 BindingDB Entry DOI: 10.7270/Q2VQ31HW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain testis 1 (BRDT(1)) (Homo sapiens (Human)) | BDBM205435 ((6S+2S)-PEG7 (11)) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.59 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Dana-Farber Cancer Institute | Assay Description Assays were performed with minor modifications from the manufacturer's protocol (PerkinElmer, USA). All reagents were diluted in 50 mM HEPES, 150... | Nat Chem Biol 12: 1089-1096 (2016) Article DOI: 10.1038/nchembio.2209 BindingDB Entry DOI: 10.7270/Q2VQ31HW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 (BRD4) (aa 44-168) (Homo sapiens (Human)) | BDBM205435 ((6S+2S)-PEG7 (11)) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.789 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Dana-Farber Cancer Institute | Assay Description Assays were performed with minor modifications from the manufacturer's protocol (PerkinElmer, USA). All reagents were diluted in 50 mM HEPES, 150... | Nat Chem Biol 12: 1089-1096 (2016) Article DOI: 10.1038/nchembio.2209 BindingDB Entry DOI: 10.7270/Q2VQ31HW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
BET bromodomain 4(1,2) (BRD4(1,2)) (Homo sapiens (Human)) | BDBM205435 ((6S+2S)-PEG7 (11)) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 0.00590 | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute | Assay Description Refer to DiscoverX | Nat Chem Biol 12: 1089-1096 (2016) Article DOI: 10.1038/nchembio.2209 BindingDB Entry DOI: 10.7270/Q2VQ31HW | |||||||||||
More data for this Ligand-Target Pair |