null
SMILES: Cc1nc(C)c(Cn2c3ccc(cc3n(-c3ncns3)c2=O)S(=O)(=O)NC2(C)CC2)s1
InChI Key: InChIKey=FLUZEVGWXJVSPX-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Poly(ADP-ribose) glycohydrolase (Homo sapiens (Human)) | BDBM205480 (PDD00017238 (5) | US10508086, Example 90 | US10995...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | 7.4 | n/a |
University of Manchester | Assay Description Briefly, PARG in vitro assays were conducted in a total volume of 15 μL in a standard 384-well format. A total of 5 μL of human full length... | ACS Chem Biol 11: 3179-3190 (2016) Article DOI: 10.1021/acschembio.6b00609 BindingDB Entry DOI: 10.7270/Q2BP01NJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly(ADP-ribose) glycohydrolase (Homo sapiens (Human)) | BDBM205480 (PDD00017238 (5) | US10508086, Example 90 | US10995...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 40 | n/a | n/a | n/a | n/a |
Cancer Research Technology Limited US Patent | Assay Description PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ... | US Patent US10508086 (2019) BindingDB Entry DOI: 10.7270/Q26112QF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human)) | BDBM205480 (PDD00017238 (5) | US10508086, Example 90 | US10995...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Cancer Research Technology Limited US Patent | Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S... | US Patent US10508086 (2019) BindingDB Entry DOI: 10.7270/Q26112QF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM205480 (PDD00017238 (5) | US10508086, Example 90 | US10995...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | >1.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Cancer Research Technology Limited US Patent | Assay Description PARP1 In vitro selectivity assays were conducted as a 10 ul reaction volume in a NUNC Maxisorp 384-well assay plate pre-coated in-house with Histones... | US Patent US10995073 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly(ADP-ribose) glycohydrolase (Homo sapiens (Human)) | BDBM205480 (PDD00017238 (5) | US10508086, Example 90 | US10995...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 40 | n/a | n/a | n/a | n/a |
Cancer Research Technology Limited US Patent | Assay Description PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ... | US Patent US10995073 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ADP-ribosylhydrolase ARH3 (Homo sapiens (Human)) | BDBM205480 (PDD00017238 (5) | US10508086, Example 90 | US10995...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Cancer Research Technology Limited US Patent | Assay Description ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S... | US Patent US10995073 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human)) | BDBM205480 (PDD00017238 (5) | US10508086, Example 90 | US10995...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | >1.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Cancer Research Technology Limited US Patent | Assay Description PARP1 In vitro selectivity assays were conducted as a 10 ul reaction volume in a NUNC Maxisorp 384-well assay plate pre-coated in-house with Histones... | US Patent US10508086 (2019) BindingDB Entry DOI: 10.7270/Q26112QF | |||||||||||
More data for this Ligand-Target Pair |