BDBM20614 1-[4-(1-methylpiperidin-4-yl)phenyl]-2-phenyl-1,2,3,4-tetrahydroisoquinolin-6-ol::Piperidine Derivative, 38a

SMILES: CN1CCC(CC1)c1ccc(cc1)C1N(CCc2cc(O)ccc12)c1ccccc1

InChI Key: InChIKey=NKJJSGYHJDTRAX-UHFFFAOYSA-N

Data: 2 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 20614   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Estrogen receptor beta (Homo sapiens (Human))	BDBM20614 (1-[4-(1-methylpiperidin-4-yl)phenyl]-2-phenyl-1,2,...) Show SMILES CN1CCC(CC1)c1ccc(cc1)C1N(CCc2cc(O)ccc12)c1ccccc1 Show InChI InChI=1S/C27H30N2O/c1-28-16-13-21(14-17-28)20-7-9-22(10-8-20)27-26-12-11-25(30)19-23(26)15-18-29(27)24-5-3-2-4-6-24/h2-12,19,21,27,30H,13-18H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	266	n/a	464	n/a	n/a	7.4	22
Novartis Pharmaceuticals					Assay Description Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...				J Med Chem 48: 364-79 (2005) Article DOI: 10.1021/jm040858p BindingDB Entry DOI: 10.7270/Q2CC0XZJ
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM20614 (1-[4-(1-methylpiperidin-4-yl)phenyl]-2-phenyl-1,2,...) Show SMILES CN1CCC(CC1)c1ccc(cc1)C1N(CCc2cc(O)ccc12)c1ccccc1 Show InChI InChI=1S/C27H30N2O/c1-28-16-13-21(14-17-28)20-7-9-22(10-8-20)27-26-12-11-25(30)19-23(26)15-18-29(27)24-5-3-2-4-6-24/h2-12,19,21,27,30H,13-18H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	106	n/a	46.6	n/a	n/a	7.4	22
Novartis Pharmaceuticals					Assay Description Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...				J Med Chem 48: 364-79 (2005) Article DOI: 10.1021/jm040858p BindingDB Entry DOI: 10.7270/Q2CC0XZJ
					More data for this Ligand-Target Pair