BDBM206356 US9260415, 107

SMILES: C[C@@H](COc1cccc(Nc2cc(cn(C)c2=O)-c2ccnc(N3CCn4c5CC(C)(C)Cc5cc4C3=O)c2CO)n1)NC(=O)C=C

InChI Key: InChIKey=CZVVHLPZPFTKDM-NRFANRHFSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 206356   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM206356 (US9260415, 107) Show SMILES C[C@@H](COc1cccc(Nc2cc(cn(C)c2=O)-c2ccnc(N3CCn4c5CC(C)(C)Cc5cc4C3=O)c2CO)n1)NC(=O)C=C |r| Show InChI InChI=1S/C35H39N7O5/c1-6-30(44)37-21(2)20-47-31-9-7-8-29(39-31)38-26-14-23(18-40(5)33(26)45)24-10-11-36-32(25(24)19-43)42-13-12-41-27(34(42)46)15-22-16-35(3,4)17-28(22)41/h6-11,14-15,18,21,43H,1,12-13,16-17,19-20H2,2-5H3,(H,37,44)(H,38,39)/t21-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.612	n/a	n/a	n/a	n/a	n/a	n/a	7.5	n/a
Genentech, Inc. US Patent					Assay Description A generalized procedure for a standard biochemical Btk, Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus B...				US Patent US9260415 (2016) BindingDB Entry DOI: 10.7270/Q2WH2NT7
					More data for this Ligand-Target Pair