BDBM206614 US9260425, 372

SMILES: CCn1cc(cn1)-c1cc2c(n[nH]c2cn1)-c1cccc(n1)N1CCN(C)CC1

InChI Key: InChIKey=WKPYUMZOLALQOY-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 206614   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM206614 (US9260425, 372) Show SMILES CCn1cc(cn1)-c1cc2c(n[nH]c2cn1)-c1cccc(n1)N1CCN(C)CC1 Show InChI InChI=1S/C21H24N8/c1-3-29-14-15(12-23-29)18-11-16-19(13-22-18)25-26-21(16)17-5-4-6-20(24-17)28-9-7-27(2)8-10-28/h4-6,11-14H,3,7-10H2,1-2H3,(H,25,26)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of PIM3 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 mins in presence of ATP by caliper microfluidic mobility shift as...				J Med Chem 60: 4458-4473 (2017) Article DOI: 10.1021/acs.jmedchem.7b00418 BindingDB Entry DOI: 10.7270/Q2H997PN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM206614 (US9260425, 372) Show SMILES CCn1cc(cn1)-c1cc2c(n[nH]c2cn1)-c1cccc(n1)N1CCN(C)CC1 Show InChI InChI=1S/C21H24N8/c1-3-29-14-15(12-23-29)18-11-16-19(13-22-18)25-26-21(16)17-5-4-6-20(24-17)28-9-7-27(2)8-10-28/h4-6,11-14H,3,7-10H2,1-2H3,(H,25,26)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.268	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
Genetech, Inc. US Patent					Assay Description PIM-1, PIM-2, and PIM-3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J....				US Patent US9260425 (2016) BindingDB Entry DOI: 10.7270/Q2RR1X3X
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM206614 (US9260425, 372) Show SMILES CCn1cc(cn1)-c1cc2c(n[nH]c2cn1)-c1cccc(n1)N1CCN(C)CC1 Show InChI InChI=1S/C21H24N8/c1-3-29-14-15(12-23-29)18-11-16-19(13-22-18)25-26-21(16)17-5-4-6-20(24-17)28-9-7-27(2)8-10-28/h4-6,11-14H,3,7-10H2,1-2H3,(H,25,26)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of PIM1 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 mins in presence of ATP by caliper microfluidic mobility shift as...				J Med Chem 60: 4458-4473 (2017) Article DOI: 10.1021/acs.jmedchem.7b00418 BindingDB Entry DOI: 10.7270/Q2H997PN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM206614 (US9260425, 372) Show SMILES CCn1cc(cn1)-c1cc2c(n[nH]c2cn1)-c1cccc(n1)N1CCN(C)CC1 Show InChI InChI=1S/C21H24N8/c1-3-29-14-15(12-23-29)18-11-16-19(13-22-18)25-26-21(16)17-5-4-6-20(24-17)28-9-7-27(2)8-10-28/h4-6,11-14H,3,7-10H2,1-2H3,(H,25,26)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of PIM2 (unknown origin) using 5FAM-ARKRRRHPSGPPTA as substrate after 90 mins in presence of ATP by caliper microfluidic mobility shift as...				J Med Chem 60: 4458-4473 (2017) Article DOI: 10.1021/acs.jmedchem.7b00418 BindingDB Entry DOI: 10.7270/Q2H997PN
					More data for this Ligand-Target Pair