BDBM20662 N-methoxy-4-methyl-3-{[5-methyl-6-(2-methylpropanamido)pyrrolo[1,2-a][1,2,4]triazin-4-yl]amino}benzamide::pyrrolo[2,1-f][1,2,4]triazine analogue, 15c

SMILES: CONC(=O)c1ccc(C)c(Nc2ncnn3cc(NC(=O)C(C)C)c(C)c23)c1

InChI Key: InChIKey=ZNWHEYZTCXCRIA-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 20662   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM20662 (N-methoxy-4-methyl-3-{[5-methyl-6-(2-methylpropana...) Show SMILES CONC(=O)c1ccc(C)c(Nc2ncnn3cc(NC(=O)C(C)C)c(C)c23)c1 Show InChI InChI=1S/C20H24N6O3/c1-11(2)19(27)24-16-9-26-17(13(16)4)18(21-10-22-26)23-15-8-14(7-6-12(15)3)20(28)25-29-5/h6-11H,1-5H3,(H,24,27)(H,25,28)(H,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	120	n/a	n/a	7.5	22
Novartis Pharmaceuticals					Assay Description The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...				J Med Chem 51: 4-16 (2008) Article DOI: 10.1021/jm7009414 BindingDB Entry DOI: 10.7270/Q23T9FHB
					More data for this Ligand-Target Pair