BDBM20674 ethyl N-(4-methyl-3-{[5-methyl-6-(propan-2-ylcarbamoyl)pyrrolo[1,2-a][1,2,4]triazin-4-yl]amino}phenyl)carbamate::pyrrolo[2,1-f][1,2,4]triazine analogue, 21h

SMILES: CCOC(=O)Nc1ccc(C)c(Nc2ncnn3cc(C(=O)NC(C)C)c(C)c23)c1

InChI Key: InChIKey=FDKNVSUYRDPGNB-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 20674   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM20674 (ethyl N-(4-methyl-3-{[5-methyl-6-(propan-2-ylcarba...) Show SMILES CCOC(=O)Nc1ccc(C)c(Nc2ncnn3cc(C(=O)NC(C)C)c(C)c23)c1 Show InChI InChI=1S/C21H26N6O3/c1-6-30-21(29)25-15-8-7-13(4)17(9-15)26-19-18-14(5)16(20(28)24-12(2)3)10-27(18)23-11-22-19/h7-12H,6H2,1-5H3,(H,24,28)(H,25,29)(H,22,23,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.70	n/a	110	n/a	n/a	n/a	n/a
Novartis Pharmaceuticals					Assay Description The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...				J Med Chem 51: 4-16 (2008) Article DOI: 10.1021/jm7009414 BindingDB Entry DOI: 10.7270/Q23T9FHB
					More data for this Ligand-Target Pair