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SMILES: CC(C)c1c(CC[C@@H](O)C[C@@H](O)CC([O-])=O)n(nc1C(=O)N1CCCCC1c1ccccc1)-c1ccc(F)cc1

InChI Key: InChIKey=DGPVRQDECQBJDH-YFHSQZFMSA-M

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 20711   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM20711
PNG
(Tertiary Amide Analog, 53 | sodium (3R,5R)-7-[1-(4...)
Show SMILES CC(C)c1c(CC[C@@H](O)C[C@@H](O)CC([O-])=O)n(nc1C(=O)N1CCCCC1c1ccccc1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C31H38FN3O5/c1-20(2)29-27(16-15-24(36)18-25(37)19-28(38)39)35(23-13-11-22(32)12-14-23)33-30(29)31(40)34-17-7-6-10-26(34)21-8-4-3-5-9-21/h3-5,8-9,11-14,20,24-26,36-37H,6-7,10,15-19H2,1-2H3,(H,38,39)/p-1/t24-,25-,26?/m1/s1
PDB
MMDB

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Similars
Article
PubMed
n/an/a 6.10n/a 1.10n/an/a7.237



Pfizer



Assay Description
Enzyme Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme...

J Med Chem 51: 31-45 (2008)


Article DOI: 10.1021/jm070849r
BindingDB Entry DOI: 10.7270/Q2VD6WRD
More data for this
Ligand-Target Pair