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SMILES: COC(=O)CCCCS(C)(=O)=NC(=O)c1cnc(N)c(c1)C#Cc1cccc(c1)C(=O)Nc1cccc(C)c1

InChI Key: InChIKey=VWWWKWXBDHJDSL-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 208476   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM208476 (US9266869, 34) Show SMILES COC(=O)CCCCS(C)(=O)=NC(=O)c1cnc(N)c(c1)C#Cc1cccc(c1)C(=O)Nc1cccc(C)c1 Show InChI InChI=1S/C29H30N4O5S/c1-20-8-6-11-25(16-20)32-28(35)23-10-7-9-21(17-23)13-14-22-18-24(19-31-27(22)30)29(36)33-39(3,37)15-5-4-12-26(34)38-2/h6-11,16-19H,4-5,12,15H2,1-3H3,(H2,30,31)(H,32,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.4	30
Allergan, Inc. US Patent					Assay Description Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 ug/well of poly-Glu-Tyr (4:1) in 10 mM P...				US Patent US9266869 (2016) BindingDB Entry DOI: 10.7270/Q2NV9H33
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM208476 (US9266869, 34) Show SMILES COC(=O)CCCCS(C)(=O)=NC(=O)c1cnc(N)c(c1)C#Cc1cccc(c1)C(=O)Nc1cccc(C)c1 Show InChI InChI=1S/C29H30N4O5S/c1-20-8-6-11-25(16-20)32-28(35)23-10-7-9-21(17-23)13-14-22-18-24(19-31-27(22)30)29(36)33-39(3,37)15-5-4-12-26(34)38-2/h6-11,16-19H,4-5,12,15H2,1-3H3,(H2,30,31)(H,32,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	37
Allergan, Inc. US Patent					Assay Description Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of PDGF-induced increases in intracellular calcium l...				US Patent US9266869 (2016) BindingDB Entry DOI: 10.7270/Q2NV9H33
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM208476 (US9266869, 34) Show SMILES COC(=O)CCCCS(C)(=O)=NC(=O)c1cnc(N)c(c1)C#Cc1cccc(c1)C(=O)Nc1cccc(C)c1 Show InChI InChI=1S/C29H30N4O5S/c1-20-8-6-11-25(16-20)32-28(35)23-10-7-9-21(17-23)13-14-22-18-24(19-31-27(22)30)29(36)33-39(3,37)15-5-4-12-26(34)38-2/h6-11,16-19H,4-5,12,15H2,1-3H3,(H2,30,31)(H,32,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	7.4	30
Allergan, Inc. US Patent					Assay Description Biochemical PDGFRbeta kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 ug of poly-Glu-Tyr (4:1) in 10 mM ...				US Patent US9266869 (2016) BindingDB Entry DOI: 10.7270/Q2NV9H33
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM208476 (US9266869, 34) Show SMILES COC(=O)CCCCS(C)(=O)=NC(=O)c1cnc(N)c(c1)C#Cc1cccc(c1)C(=O)Nc1cccc(C)c1 Show InChI InChI=1S/C29H30N4O5S/c1-20-8-6-11-25(16-20)32-28(35)23-10-7-9-21(17-23)13-14-22-18-24(19-31-27(22)30)29(36)33-39(3,37)15-5-4-12-26(34)38-2/h6-11,16-19H,4-5,12,15H2,1-3H3,(H2,30,31)(H,32,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	37
Allergan, Inc. US Patent					Assay Description Automated FLIPR (Fluorometric Imaging Plate Reader) technology was used to screen for inhibitors of VEGF induced increases in intracellular calcium...				US Patent US9266869 (2016) BindingDB Entry DOI: 10.7270/Q2NV9H33
					More data for this Ligand-Target Pair