BDBM20850 7-[(4-methylpiperazin-1-yl)carbonyl]-3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2-dihydroquinolin-2-one::quinolin-2(1H)-one derivative, 9h

SMILES: CN1CCN(CC1)C(=O)c1ccc2cc(-c3csc(n3)-c3ccncc3)c(=O)[nH]c2c1

InChI Key: InChIKey=GFPPBUZAOLMYKX-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 20850   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-Dependent Kinase 5 (CDK5) (Homo sapiens (Human))	BDBM20850 (7-[(4-methylpiperazin-1-yl)carbonyl]-3-[2-(pyridin...) Show SMILES CN1CCN(CC1)C(=O)c1ccc2cc(-c3csc(n3)-c3ccncc3)c(=O)[nH]c2c1 Show InChI InChI=1S/C23H21N5O2S/c1-27-8-10-28(11-9-27)23(30)17-3-2-16-12-18(21(29)25-19(16)13-17)20-14-31-22(26-20)15-4-6-24-7-5-15/h2-7,12-14H,8-11H2,1H3,(H,25,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.40	n/a	n/a	n/a	n/a	7.5	25
Amgen					Assay Description In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...				Bioorg Med Chem Lett 17: 5384-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.045 BindingDB Entry DOI: 10.7270/Q2TD9VNG
					More data for this Ligand-Target Pair