BDBM20869 3-{2-[(pyridine-2-sulfonyl)methyl]-1,3-thiazol-4-yl}-1,2-dihydroquinolin-2-one::quinolin-2(1H)-one derivative, 17k

SMILES: O=c1[nH]c2ccccc2cc1-c1csc(CS(=O)(=O)c2ccccn2)n1

InChI Key: InChIKey=OHPFNMNHNRGIBV-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 20869   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-Dependent Kinase 5 (CDK5) (Homo sapiens (Human))	BDBM20869 (3-{2-[(pyridine-2-sulfonyl)methyl]-1,3-thiazol-4-y...) Show SMILES O=c1[nH]c2ccccc2cc1-c1csc(CS(=O)(=O)c2ccccn2)n1 Show InChI InChI=1S/C18H13N3O3S2/c22-18-13(9-12-5-1-2-6-14(12)21-18)15-10-25-16(20-15)11-26(23,24)17-7-3-4-8-19-17/h1-10H,11H2,(H,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	25
Amgen					Assay Description In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...				Bioorg Med Chem Lett 17: 5384-9 (2007) Article DOI: 10.1016/j.bmcl.2007.07.045 BindingDB Entry DOI: 10.7270/Q2TD9VNG
					More data for this Ligand-Target Pair