BDBM209050 US9243038, 25

SMILES: NC(=O)CC[C@@H]1NC(=O)\C=C/C(=O)NNCCCC(NCCCCNC(=O)[C@@H](Cc2ccc(cc2)C(=O)c2ccccc2)NC(=O)[C@H](CC2CCCCC2)NC1=O)C(N)=O

InChI Key: InChIKey=YZGGXYJEJGRNJU-KNCQIRRISA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 209050   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
insulin-degrading enzyme isoform 1 precursor (Homo sapiens (Human))	BDBM209050 (US9243038, 25) Show SMILES NC(=O)CC[C@@H]1NC(=O)\C=C/C(=O)NNCCCC(NCCCCNC(=O)[C@@H](Cc2ccc(cc2)C(=O)c2ccccc2)NC(=O)[C@H](CC2CCCCC2)NC1=O)C(N)=O |r,c:9| Show InChI InChI=1S/C43H59N9O8/c44-36(53)20-19-33-42(59)51-35(26-28-10-3-1-4-11-28)43(60)50-34(27-29-15-17-31(18-16-29)39(56)30-12-5-2-6-13-30)41(58)47-24-8-7-23-46-32(40(45)57)14-9-25-48-52-38(55)22-21-37(54)49-33/h2,5-6,12-13,15-18,21-22,28,32-35,46,48H,1,3-4,7-11,14,19-20,23-27H2,(H2,44,53)(H2,45,57)(H,47,58)(H,49,54)(H,50,60)(H,51,59)(H,52,55)/b22-21-/t32?,33-,34+,35-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
President and Fellows of Harvard College US Patent					Assay Description Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...				US Patent US9243038 (2016) BindingDB Entry DOI: 10.7270/Q2MW2FZV
					More data for this Ligand-Target Pair