BDBM209171 US9266877, 117

SMILES: OC(=O)c1nc(ccc1-c1cccc(OC2CCCCC2)c1Cl)N1CCc2cccc(C(=O)Nc3nc4ccccc4s3)c2C1

InChI Key: InChIKey=LJCPCILNFOCKSA-UHFFFAOYSA-N

Data: 1 KI  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 209171   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bcl-2-like protein 1 (Homo sapiens (Human))	BDBM209171 (US9266877, 117) Show SMILES OC(=O)c1nc(ccc1-c1cccc(OC2CCCCC2)c1Cl)N1CCc2cccc(C(=O)Nc3nc4ccccc4s3)c2C1 Show InChI InChI=1S/C35H31ClN4O4S/c36-31-23(11-7-14-28(31)44-22-9-2-1-3-10-22)24-16-17-30(38-32(24)34(42)43)40-19-18-21-8-6-12-25(26(21)20-40)33(41)39-35-37-27-13-4-5-15-29(27)45-35/h4-8,11-17,22H,1-3,9-10,18-20H2,(H,42,43)(H,37,39,41)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.100	<-13.6	n/a	n/a	n/a	n/a	n/a	n/a	25
ABBVIE INC. US Patent					Assay Description The measurement of competition of compounds of Formula (I) with F-Bak for a Bcl-2 family protein (Bcl-xL) binding site using a Time Resolved Fluoresc...				US Patent US9266877 (2016) BindingDB Entry DOI: 10.7270/Q2H41Q7V
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-XL (Mus musculus (Mouse))	BDBM209171 (US9266877, 117) Show SMILES OC(=O)c1nc(ccc1-c1cccc(OC2CCCCC2)c1Cl)N1CCc2cccc(C(=O)Nc3nc4ccccc4s3)c2C1 Show InChI InChI=1S/C35H31ClN4O4S/c36-31-23(11-7-14-28(31)44-22-9-2-1-3-10-22)24-16-17-30(38-32(24)34(42)43)40-19-18-21-8-6-12-25(26(21)20-40)33(41)39-35-37-27-13-4-5-15-29(27)45-35/h4-8,11-17,22H,1-3,9-10,18-20H2,(H,42,43)(H,37,39,41)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	131	n/a	n/a	n/a	n/a
ABBVIE INC. US Patent					Assay Description The efficacy of the compounds of Formula (I) can also be determined in cell-based killing assays using a variety of cell lines and mouse tumor models...				US Patent US9266877 (2016) BindingDB Entry DOI: 10.7270/Q2H41Q7V
					More data for this Ligand-Target Pair