BDBM209188 US9266877, 134

SMILES: COCCC1(Cn2ncc(c2C)-c2ccc(nc2C(O)=O)N2CCc3cccc(C(=O)Nc4nc5ccccc5s4)c3C2)CCCCCC1

InChI Key: InChIKey=DGPHUOWUXMACOK-UHFFFAOYSA-N

Data: 1 KI  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 209188   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bcl-2-like protein 1 (Homo sapiens (Human))	BDBM209188 (US9266877, 134) Show SMILES COCCC1(Cn2ncc(c2C)-c2ccc(nc2C(O)=O)N2CCc3cccc(C(=O)Nc4nc5ccccc5s4)c3C2)CCCCCC1 Show InChI InChI=1S/C38H42N6O4S/c1-25-29(22-39-44(25)24-38(19-21-48-2)17-7-3-4-8-18-38)27-14-15-33(41-34(27)36(46)47)43-20-16-26-10-9-11-28(30(26)23-43)35(45)42-37-40-31-12-5-6-13-32(31)49-37/h5-6,9-15,22H,3-4,7-8,16-21,23-24H2,1-2H3,(H,46,47)(H,40,42,45)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.100	<-13.6	n/a	n/a	n/a	n/a	n/a	n/a	25
ABBVIE INC. US Patent					Assay Description The measurement of competition of compounds of Formula (I) with F-Bak for a Bcl-2 family protein (Bcl-xL) binding site using a Time Resolved Fluoresc...				US Patent US9266877 (2016) BindingDB Entry DOI: 10.7270/Q2H41Q7V
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-XL (Mus musculus (Mouse))	BDBM209188 (US9266877, 134) Show SMILES COCCC1(Cn2ncc(c2C)-c2ccc(nc2C(O)=O)N2CCc3cccc(C(=O)Nc4nc5ccccc5s4)c3C2)CCCCCC1 Show InChI InChI=1S/C38H42N6O4S/c1-25-29(22-39-44(25)24-38(19-21-48-2)17-7-3-4-8-18-38)27-14-15-33(41-34(27)36(46)47)43-20-16-26-10-9-11-28(30(26)23-43)35(45)42-37-40-31-12-5-6-13-32(31)49-37/h5-6,9-15,22H,3-4,7-8,16-21,23-24H2,1-2H3,(H,46,47)(H,40,42,45)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.900	n/a	n/a	n/a	n/a
ABBVIE INC. US Patent					Assay Description The efficacy of the compounds of Formula (I) can also be determined in cell-based killing assays using a variety of cell lines and mouse tumor models...				US Patent US9266877 (2016) BindingDB Entry DOI: 10.7270/Q2H41Q7V
					More data for this Ligand-Target Pair