BDBM20973 8-[butyl(ethyl)amino]-4-(4-methoxy-2-methylphenyl)-6-methyl-1H,2H,3H,4H-pyrido[2,3-b]pyrazin-2-one::CHEMBL189089::Pyridopyrazinone, 1a

SMILES: CCCCN(CC)c1cc(C)nc2N(CC(=O)Nc12)c1ccc(OC)cc1C

InChI Key: InChIKey=LYSNALHFMZZUFA-UHFFFAOYSA-N

Data: 1 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 20973   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin releasing factor receptor 1 (Homo sapiens (Human))	BDBM20973 (8-[butyl(ethyl)amino]-4-(4-methoxy-2-methylphenyl)...) Show SMILES CCCCN(CC)c1cc(C)nc2N(CC(=O)Nc12)c1ccc(OC)cc1C Show InChI InChI=1S/C22H30N4O2/c1-6-8-11-25(7-2)19-13-16(4)23-22-21(19)24-20(27)14-26(22)18-10-9-17(28-5)12-15(18)3/h9-10,12-13H,6-8,11,14H2,1-5H3,(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Emory University Curated by ChEMBL					Assay Description Displacement of [125I]-Tyr0-sauvagine from human CRF1 receptor expressed in HEK293T cells after 2 hrs by scintillation counting				Bioorg Med Chem Lett 25: 5111-4 (2015) BindingDB Entry DOI: 10.7270/Q2XW4MM0
					More data for this Ligand-Target Pair
Corticotropin releasing factor receptor (Rattus norvegicus (rat))	BDBM20973 (8-[butyl(ethyl)amino]-4-(4-methoxy-2-methylphenyl)...) Show SMILES CCCCN(CC)c1cc(C)nc2N(CC(=O)Nc12)c1ccc(OC)cc1C Show InChI InChI=1S/C22H30N4O2/c1-6-8-11-25(7-2)19-13-16(4)23-22-21(19)24-20(27)14-26(22)18-10-9-17(28-5)12-15(18)3/h9-10,12-13H,6-8,11,14H2,1-5H3,(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.920	n/a	n/a	n/a	n/a	7.0	23
Bristol-Myers Squibb Company					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 50: 2269-72 (2007) Article DOI: 10.1021/jm0611410 BindingDB Entry DOI: 10.7270/Q25Q4TCS
					More data for this Ligand-Target Pair
Corticotropin releasing factor receptor (Rattus norvegicus (rat))	BDBM20973 (8-[butyl(ethyl)amino]-4-(4-methoxy-2-methylphenyl)...) Show SMILES CCCCN(CC)c1cc(C)nc2N(CC(=O)Nc12)c1ccc(OC)cc1C Show InChI InChI=1S/C22H30N4O2/c1-6-8-11-25(7-2)19-13-16(4)23-22-21(19)24-20(27)14-26(22)18-10-9-17(28-5)12-15(18)3/h9-10,12-13H,6-8,11,14H2,1-5H3,(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.920	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of [125I]-ovine-CRF binding to corticotropin releasing factor receptor 1				J Med Chem 47: 5783-90 (2004) Article DOI: 10.1021/jm049737f BindingDB Entry DOI: 10.7270/Q2S75FT6
					More data for this Ligand-Target Pair