BDBM20978 N-butyl-4-(2,6-dimethoxypyridin-3-yl)-N-ethyl-6-methyl-1H,2H,3H,4H-pyrido[2,3-b]pyrazin-8-amine::Pyridopyrazine, 2b

SMILES: CCCCN(CC)c1cc(C)nc2N(CCNc12)c1ccc(OC)nc1OC

InChI Key: InChIKey=ZJEDWKRGKJFPCF-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 20978   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin-releasing factor receptor 1 (Rattus norvegicus (rat))	BDBM20978 (N-butyl-4-(2,6-dimethoxypyridin-3-yl)-N-ethyl-6-me...) Show SMILES CCCCN(CC)c1cc(C)nc2N(CCNc12)c1ccc(OC)nc1OC Show InChI InChI=1S/C21H31N5O2/c1-6-8-12-25(7-2)17-14-15(3)23-20-19(17)22-11-13-26(20)16-9-10-18(27-4)24-21(16)28-5/h9-10,14,22H,6-8,11-13H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	7.0	23
Bristol-Myers Squibb Company					Assay Description The IC50 values were measured by monitoring the inhibition effects of test compounds on [125I]-o-CRF binding to rat cortex in vitro.				J Med Chem 50: 2269-72 (2007) Article DOI: 10.1021/jm0611410 BindingDB Entry DOI: 10.7270/Q25Q4TCS
					More data for this Ligand-Target Pair