BDBM210021 US10576087, Compound 2.27::US9273046, 2.27::US9895376, Compound 2.27
SMILES: Oc1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
InChI Key:
Data: 6 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase B-raf (Homo sapiens (Human)) | BDBM210021 (US10576087, Compound 2.27 | US9273046, 2.27 | US98...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | 25 |
BeiGene, LTD. US Patent | Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res... | US Patent US9273046 (2016) BindingDB Entry DOI: 10.7270/Q28G8JK6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM210021 (US10576087, Compound 2.27 | US9273046, 2.27 | US98...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <0.25 | n/a | n/a | n/a | n/a | n/a | 25 |
BeiGene, LTD. US Patent | Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res... | US Patent US9273046 (2016) BindingDB Entry DOI: 10.7270/Q28G8JK6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-Raf (Y340D/Y341D) (Homo sapiens (Human)) | BDBM210021 (US10576087, Compound 2.27 | US9273046, 2.27 | US98...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <0.25 | n/a | n/a | n/a | n/a | n/a | n/a |
BEIGENE, LTD. US Patent | Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res... | US Patent US10576087 (2020) BindingDB Entry DOI: 10.7270/Q2HM5BVQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-RAF (Y340D Y341D) (Homo sapiens (Human)) | BDBM210021 (US10576087, Compound 2.27 | US9273046, 2.27 | US98...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <0.25 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute | Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res... | J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
B-RAF V600E (Homo sapiens (Human)) | BDBM210021 (US10576087, Compound 2.27 | US9273046, 2.27 | US98...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
BEIGENE, LTD. US Patent | Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res... | US Patent US10576087 (2020) BindingDB Entry DOI: 10.7270/Q2HM5BVQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
B-RAF V600E (Homo sapiens (Human)) | BDBM210021 (US10576087, Compound 2.27 | US9273046, 2.27 | US98...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute | Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res... | J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2V40XG6 | |||||||||||
More data for this Ligand-Target Pair |