null
SMILES: Cc1cc2[nH]c(nc2cc1F)C1[C@@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@H]12
InChI Key:
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM210045 (US9273046, 2.4a) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.540 | n/a | n/a | n/a | n/a | n/a | 25 |
BeiGene, LTD. US Patent | Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res... | US Patent US9273046 (2016) BindingDB Entry DOI: 10.7270/Q28G8JK6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase B-raf (Homo sapiens (Human)) | BDBM210045 (US9273046, 2.4a) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | 25 |
BeiGene, LTD. US Patent | Assay Description Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res... | US Patent US9273046 (2016) BindingDB Entry DOI: 10.7270/Q28G8JK6 | |||||||||||
More data for this Ligand-Target Pair |