null
SMILES: CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)C1CCCC1
InChI Key: InChIKey=FFBDFADSZUINTG-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Adenosine receptor A1 (GUINEA PIG) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | PubMed | 6.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd. Curated by ChEMBL | Assay Description Binding affinity against adenosine A1 receptor using N6-[3H]cyclohexyladenosine as radioligand in guinea pig forebrain membranes | J Med Chem 35: 924-30 (1992) BindingDB Entry DOI: 10.7270/Q2NS0VJZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (GUINEA PIG) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 6.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of N6-[3H]cyclohexyladenosine from adenosine receptor A1 in guinea pig forebrain membranes by liquid scintillation counting method | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00829 BindingDB Entry DOI: 10.7270/Q22J6GHJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 6.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Urbino Carlo Bo Curated by ChEMBL | Assay Description Binding affinity towards human Adenosine A1 receptor expressed in CHO cells using 1 nM [3H]DPCPX | J Med Chem 48: 6887-96 (2005) Article DOI: 10.1021/jm058018d BindingDB Entry DOI: 10.7270/Q28C9X1X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 6.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Pisa Curated by ChEMBL | Assay Description Binding affinity against adenosine A1 receptor in human cortical membranes using [3H]-CHA as radioligand | J Med Chem 47: 3019-31 (2004) Article DOI: 10.1021/jm030977p BindingDB Entry DOI: 10.7270/Q2BC3Z07 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | PubMed | 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Cadus Pharmaceutical Corporation Curated by ChEMBL | Assay Description Inhibitory activity against binding of the [3H]-CGS-21,680 to human A2a receptor (hA2a) radioligands using competition binding assay | Bioorg Med Chem Lett 9: 2413-8 (1999) BindingDB Entry DOI: 10.7270/Q2PR7V5N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University Curated by ChEMBL | Assay Description Binding affinity for human Adenosine A1 receptor | J Med Chem 47: 663-72 (2004) Article DOI: 10.1021/jm030863d BindingDB Entry DOI: 10.7270/Q2XG9QJ3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 12.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Aix-Marseille Universit£ Curated by ChEMBL | Assay Description Binding affinity to adenosine receptor A1 | Bioorg Med Chem Lett 19: 6736-9 (2009) Article DOI: 10.1016/j.bmcl.2009.09.112 BindingDB Entry DOI: 10.7270/Q2VT1S67 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2b (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Ferrara Curated by PDSP Ki Database | Mol Pharmacol 61: 415-24 (2002) Article DOI: 10.1124/mol.61.2.415 BindingDB Entry DOI: 10.7270/Q28C9TT0 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of [3H]DPCPX from human A1 adenosine receptor expressed in CHO-K1 cells by radioligand binding assay | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c02067 BindingDB Entry DOI: 10.7270/Q2CV4NM3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2b (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 51 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn Curated by ChEMBL | Assay Description Inhibition of [3H]ZM-241,385 binding to adenosine A2b receptor | J Med Chem 48: 2108-14 (2005) Article DOI: 10.1021/jm049513x BindingDB Entry DOI: 10.7270/Q2154HVK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2b (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 51 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Dipartimento di Scienze Farmaceutiche Curated by ChEMBL | Assay Description Displacement of [3H]DPCPX from human adenosine A2b receptor expressed in HEK293 cells after 30 mins | Bioorg Med Chem 18: 7890-9 (2010) Article DOI: 10.1016/j.bmc.2010.09.043 BindingDB Entry DOI: 10.7270/Q2V12510 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2b (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | PubMed | 51 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn Curated by ChEMBL | Assay Description Inhibition of [3H]-ZM-241,385 binding to human adenosine A2B receptor | J Med Chem 45: 1500-10 (2002) BindingDB Entry DOI: 10.7270/Q2X929MN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2b (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 56 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
East China University of Science and Technology Curated by ChEMBL | Assay Description Antagonist activity against human adenosine A2B receptor | Eur J Med Chem 45: 3459-71 (2010) Article DOI: 10.1016/j.ejmech.2010.04.039 BindingDB Entry DOI: 10.7270/Q2K074GG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 56 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Urbino Carlo Bo Curated by ChEMBL | Assay Description Binding affinity towards human Adenosine A2a receptor expressed in HEK293 cells using 6 nM [3H]CGS-21680 | J Med Chem 48: 6887-96 (2005) Article DOI: 10.1021/jm058018d BindingDB Entry DOI: 10.7270/Q28C9X1X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2b (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 56 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CV Therapeutics Inc. Curated by ChEMBL | Assay Description Displacement of [3H]ZM241385 from human adenosine A2b receptor expressed in HEK cells | J Med Chem 49: 3682-92 (2006) Article DOI: 10.1021/jm051268+ BindingDB Entry DOI: 10.7270/Q21V5DMG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2b (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | PubMed | 63.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes & Digestive & Kidney Diseases Curated by ChEMBL | Assay Description Binding affinity at human Adenosine A2B receptor expressed in HEK-293 cells, using [125I]-ABOPX as radioligand | J Med Chem 45: 2131-8 (2002) BindingDB Entry DOI: 10.7270/Q2V1243G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a/A2b (Rattus norvegicus-Rattus norvegicus (rat)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | PubMed | 69 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Curated by ChEMBL | Assay Description Antagonistic activity against adenosine A2 receptor in rat adipocytes | J Med Chem 33: 1906-10 (1990) BindingDB Entry DOI: 10.7270/Q22F7MD6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | PubMed | 70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Cadus Pharmaceutical Corporation Curated by ChEMBL | Assay Description Inhibitory activity against binding of [3H]-DPCPX to human A1 receptor (hA1) using competition binding assay | Bioorg Med Chem Lett 9: 2413-8 (1999) BindingDB Entry DOI: 10.7270/Q2PR7V5N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2b (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 73 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University Curated by ChEMBL | Assay Description Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells after 30 mins | J Med Chem 59: 1967-83 (2016) Article DOI: 10.1021/acs.jmedchem.5b01586 BindingDB Entry DOI: 10.7270/Q2QF8VS9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2b (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 73 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University Curated by ChEMBL | Assay Description Displacement [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation counting method | J Med Chem 63: 7721-7739 (2020) Article DOI: 10.1021/acs.jmedchem.0c00564 BindingDB Entry DOI: 10.7270/Q2WD444S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2b (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 73 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University Curated by ChEMBL | Assay Description Displacement of [3H]DPCPX from human adenosine A2B receptor expressed in HEK293 cell membranes after 30 mins | J Med Chem 60: 3372-3382 (2017) Article DOI: 10.1021/acs.jmedchem.7b00138 BindingDB Entry DOI: 10.7270/Q2TQ6407 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2b (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 73 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of [3H]DPCPX from human A2BAR expressed in HEK293 cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysis | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01636 BindingDB Entry DOI: 10.7270/Q2M61Q5K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A1 (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 95 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Institute of Pharmaceutical Sciences Curated by ChEMBL | Assay Description Displacement of [3H]DPCPX from human cloned adenosine A1 receptor expressed in CHOK1 cells by scintillation counting | Eur J Med Chem 44: 2122-7 (2009) Article DOI: 10.1016/j.ejmech.2008.10.017 BindingDB Entry DOI: 10.7270/Q2S182CW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 97 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze Curated by ChEMBL | Assay Description Displacement of [3H]ZM241385 from human A2AR expressed in CHO cell membranes measured after 60 mins by scintillation counting method | J Med Chem 62: 6894-6912 (2019) Article DOI: 10.1021/acs.jmedchem.9b00106 BindingDB Entry DOI: 10.7270/Q2PC35TK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 129 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universität Würzburg Curated by PDSP Ki Database | Naunyn Schmiedebergs Arch Pharmacol 357: 1-9 (1998) Article DOI: 10.1007/pl00005131 BindingDB Entry DOI: 10.7270/Q20Z71T3 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 129 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden/Amsterdam Center for Drug Research Curated by PDSP Ki Database | Assay Description Displacement of [3H]-ZM 241385 binding to human adenosine A2A receptor expressed in CHO cells | J Med Chem 48: 2045-53 (2005) Article DOI: 10.1021/jm049597+ BindingDB Entry DOI: 10.7270/Q28P6188 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 129 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden/Amsterdam Center for Drug Research Curated by ChEMBL | Assay Description Displacement of [3H]ZM-241385 from human adenosine A2A receptor expressed in HEK293 cells | Bioorg Med Chem 16: 2741-52 (2008) Article DOI: 10.1016/j.bmc.2008.01.013 BindingDB Entry DOI: 10.7270/Q2K35VHW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Displacement of [3H]NECA from human adenosine A2A receptor expressed in CHO cells | J Med Chem 53: 3954-63 (2010) Article DOI: 10.1021/jm901785w BindingDB Entry DOI: 10.7270/Q2N017HH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden/Amsterdam Center for Drug Research Curated by ChEMBL | Assay Description Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cell membrane | J Med Chem 51: 4449-55 (2008) Article DOI: 10.1021/jm701594y BindingDB Entry DOI: 10.7270/Q2T72JBB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Camerino Curated by ChEMBL | Assay Description Displacement of [3H]NECA from human adenosine A2A receptor expressed in CHO cells | Bioorg Med Chem 17: 2812-22 (2009) Article DOI: 10.1016/j.bmc.2009.02.030 BindingDB Entry DOI: 10.7270/Q25Q4X1J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Institute of Pharmaceutical Sciences Curated by ChEMBL | Assay Description Displacement of [3H]ZM-241385 from human cloned adenosine A2A receptor expressed in HEK293 cells by scintillation counting | Eur J Med Chem 44: 2122-7 (2009) Article DOI: 10.1016/j.ejmech.2008.10.017 BindingDB Entry DOI: 10.7270/Q2S182CW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a/A2b (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | PubMed | 140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institutes of Health Curated by ChEMBL | Assay Description Inhibition of the stimulation by 5'-(N-ethylcarbamoyl) adenosine of adenyl cyclase via adenosine A2 receptor in human platelet membranes. | J Med Chem 32: 1231-7 (1989) BindingDB Entry DOI: 10.7270/Q2PZ57T1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a/A2b (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | PubMed | 140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes, Digestive and Kidney Diseases Curated by ChEMBL | Assay Description Inhibition of 5'-(N-ethylcarbamoyl)adenosine-elicited stimulation of adenylate cyclase in human platelet membranes | J Med Chem 31: 613-7 (1988) BindingDB Entry DOI: 10.7270/Q2Q52RVX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 144 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Pisa Curated by ChEMBL | Assay Description Binding affinity against adenosine A2 receptor in human striatal membranes using [3H]-CGS-21,680 as radioligand | J Med Chem 47: 3019-31 (2004) Article DOI: 10.1021/jm030977p BindingDB Entry DOI: 10.7270/Q2BC3Z07 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a/A2b (Rattus norvegicus-Rattus norvegicus (rat)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 151 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fujisawa Pharmaceutical Company, Ltd. Curated by ChEMBL | Assay Description Adenosine A2 receptor binding using [3H]CGS-21680 in rat striatal membranes | J Med Chem 42: 779-83 (1999) Article DOI: 10.1021/jm980671w BindingDB Entry DOI: 10.7270/Q2J105WN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 156 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Ferrara Curated by PDSP Ki Database | Mol Pharmacol 61: 415-24 (2002) Article DOI: 10.1124/mol.61.2.415 BindingDB Entry DOI: 10.7270/Q28C9TT0 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 157 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University Curated by ChEMBL | Assay Description Displacement of [3H]ZM241385 from human Adenosine A2A receptor expressed in HeLa cells after 30 mins | J Med Chem 59: 1967-83 (2016) Article DOI: 10.1021/acs.jmedchem.5b01586 BindingDB Entry DOI: 10.7270/Q2QF8VS9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Rattus norvegicus (rat)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 157 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University College of Pharmaceutical Sciences Curated by ChEMBL | Assay Description Displacement of [3H]MSX2 from rat adenosine A2A receptor | Eur J Med Chem 43: 614-20 (2008) Article DOI: 10.1016/j.ejmech.2007.05.001 BindingDB Entry DOI: 10.7270/Q22Z15BT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 157 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of [3H]HZ241385 from human A2AAR expressed in HeLa cell membrane incubated for 30 mins by microbeta trilux scintillation counter analysi... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01636 BindingDB Entry DOI: 10.7270/Q2M61Q5K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 157 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of [3H]ZM2421385 from adenosine A2A receptor expressed in human HeLa cell membranes incubated for 30 mins by scintillation counting meth... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01431 BindingDB Entry DOI: 10.7270/Q2JQ14S5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 157 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University Curated by ChEMBL | Assay Description Displacement [3H]ZM241385 from adenosine A2A receptor in human HeLa cell membranes incubated for 30 mins by scintillation counting method | J Med Chem 63: 7721-7739 (2020) Article DOI: 10.1021/acs.jmedchem.0c00564 BindingDB Entry DOI: 10.7270/Q2WD444S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 157 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Uppsala University Curated by ChEMBL | Assay Description Displacement of [3H]4-(2-[7-amino-2-(2-furyl)[1,2,4]triazolo[2,3-a][1,3,5]triazin-5-ylamino]ethyl)phenol from human adenosine A2A receptor expressed ... | J Med Chem 60: 3372-3382 (2017) Article DOI: 10.1021/acs.jmedchem.7b00138 BindingDB Entry DOI: 10.7270/Q2TQ6407 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Rattus norvegicus (rat)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 157 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn Curated by ChEMBL | Assay Description Displacement of [3H]MSX2 from adenosine A2A receptor in rat brain striatum membrane | Bioorg Med Chem 18: 2195-203 (2010) Article DOI: 10.1016/j.bmc.2010.01.072 BindingDB Entry DOI: 10.7270/Q2BZ670J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Rattus norvegicus (rat)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 157 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Chemical Technology Curated by ChEMBL | Assay Description Displacement of [3H]MSX-2 from adenosine A2A receptor in rat brain striatal membrane after 30 mins by scintillation counting | Eur J Med Chem 45: 1739-45 (2010) Article DOI: 10.1016/j.ejmech.2009.12.075 BindingDB Entry DOI: 10.7270/Q2N016NW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Rattus norvegicus (rat)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 178 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
ZENECA Pharmaceuticals Curated by PDSP Ki Database | Br J Pharmacol 115: 1096-102 (1995) Article DOI: 10.1111/j.1476-5381.1995.tb15923.x BindingDB Entry DOI: 10.7270/Q2377766 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2b (Rattus norvegicus) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | PubMed | 186 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes & Digestive & Kidney Diseases Curated by ChEMBL | Assay Description Inhibition of [125I]-APOBX binding to rat Adenosine A2B receptor expressed in HEK cells | J Med Chem 45: 2131-8 (2002) BindingDB Entry DOI: 10.7270/Q2V1243G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A3 (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vrije Universiteit Curated by ChEMBL | Assay Description Displacement of [125I]-AB-MECA from human adenosine A3 receptor expressed in CHO cells | J Med Chem 41: 3987-93 (1998) Article DOI: 10.1021/jm980036q BindingDB Entry DOI: 10.7270/Q2D21WR1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Pisa Curated by ChEMBL | Assay Description Binding affinity against adenosine A2 receptor in bovine striatal membranes using [3H]-CGS-21,680 as radioligand | J Med Chem 47: 3019-31 (2004) Article DOI: 10.1021/jm030977p BindingDB Entry DOI: 10.7270/Q2BC3Z07 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a (Homo sapiens (Human)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 226 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NIDDK Curated by ChEMBL | Assay Description Binding affinity for HA-tagged wild type human Adenosine A2A receptor (WT) using [3H]CGS-21680 as radioligand expressed in COS-7 cells | J Med Chem 40: 2588-95 (1997) Article DOI: 10.1021/jm970084v BindingDB Entry DOI: 10.7270/Q27M08MC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosine receptor A2a/A2b (Rattus norvegicus-Rattus norvegicus (rat)) | BDBM21173 (1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | PubMed | 230 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd Curated by ChEMBL | Assay Description Inhibition of N-[3H]-ethyladenosin-5''-uronamide binding to adenosine A2 receptor from rat striatal membranes | J Med Chem 35: 2342-5 (1992) BindingDB Entry DOI: 10.7270/Q2T43S20 | |||||||||||
More data for this Ligand-Target Pair |
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